MST1R: A Potential Drug Target for Gastrointestinal Diseases (G4486)

Target Name: MST1R

NCBI ID: G4486

MST1R

MST1R: A Potential Drug Target for Gastrointestinal Diseases

MST1R (MST1 receptor type 1) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the MSTN (scaffolded protein/nucleic acid binding protein) family, which is known for its role in cell-signaling pathways. MST1R is highly expressed in the gastrointestinal tract, which makes it a potential drug target or biomarker in the treatment of various gastrointestinal diseases.

The MSTN family consists of four subfamilies, including MST1R, MST2R, MST3R, and MSTRN (MSTN gene). MST1R is the most well-studied member of the family, and its function has been extensively investigated. MST1R is a 21-kDa protein that is expressed in various tissues, including the brain, pancreas, and gastrointestinal tract. It is highly expressed in the gastrointestinal tract, making it a potential drug target or biomarker in the treatment of various gastrointestinal diseases.

One of the key functions of MST1R is its role in cell-signaling pathways. MST1R is a member of the MSTN family, which is known for its role in cell-signaling pathways. MST1R plays a key role in the regulation of cellular processes that are involved in cell survival, growth, and differentiation. It is highly expressed in various tissues, including the brain, pancreas, and gastrointestinal tract, which makes it a potential drug target or biomarker in the treatment of various gastrointestinal diseases.

MST1R is involved in various cellular processes that are involved in cell survival, growth, and differentiation. It is a key regulator of the Wnt signaling pathway, which is involved in the regulation of cellular processes that are involved in cell survival, growth, and differentiation. . The Wnt signaling pathway is a critical regulator of development and growth, and it is involved in the formation of various tissues in the body, including the brain, pancreas, and gastrointestinal tract.

MST1R is also involved in the regulation of the Notch signaling pathway, which is involved in the regulation of cellular processes that are involved in cell survival, growth, and differentiation. The Notch signaling pathway is a critical regulator of development and growth, and it is involved in the formation of various tissues in the body, including the brain, pancreas, and gastrointestinal tract.

MST1R is also involved in the regulation of the TGF-β signaling pathway, which is involved in the regulation of cellular processes that are involved in cell survival, growth, and differentiation. The TGF-β signaling pathway is a critical regulator of development and growth , and it is involved in the formation of various tissues in the body, including the brain, pancreas, and gastrointestinal tract.

MST1R is a potential drug target or biomarker in the treatment of various gastrointestinal diseases. Its function in cell-signaling pathways makes it an attractive target for small molecules that can modulate its activity. Several studies have investigated the potential therapeutic benefits of small molecules that can modulate MST1R activity. These studies have shown that small molecules can significantly improve the efficacy of various treatments for gastrointestinal diseases, including cancer, inflammatory bowel disease, and gastrointestinal infections.

In conclusion, MST1R is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the MSTN family, which is known for its role in cell-signaling pathways. MST1R is highly expressed in the gastrointestinal tract, making it a potential drug target or biomarker in the treatment of various gastrointestinal diseases. Its function in cell

Protein Name: Macrophage Stimulating 1 Receptor

Functions: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand

The "MST1R Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MST1R comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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