MSRB1 as A Potential Drug Target for Detoxifying Methionine (G51734)

Target Name: MSRB1

NCBI ID: G51734

MSRB1

MSRB1 as A Potential Drug Target for Detoxifying Methionine

MSRB1 (Methionine sulfoxide reductase B1) is a gene that encodes a protein located in the mitochondria. The protein is involved in a critical cellular process called the detoxification of methionine, which is a sulfur compound that is normally produced by the body but can also be produced by some bacteria and fungi. Methionine is important for many different cellular processes in the body, including the production of proteins, neurotransmitters, and antioxidants. However, when methionine is produced in high levels or is difficult to eliminate from the body, it can cause a variety of health problems, including damage to the liver, heart, and brain.

The MSRB1 gene has been identified as a potential drug target or biomarker for a variety of diseases. One of the main reasons for its potential as a drug target is its involvement in the detoxification of methionine, which is a key step in the production of many essential compounds that the body needs to function properly. Methionine is a precursor to many of these compounds, including proteins, neurotransmitters, and antioxidants. Therefore, any drug that can effectively reduce the production or levels of methionine in the body could potentially be used to treat a variety of diseases.

In addition to its role in the detoxification of methionine, MSRB1 is also involved in a number of other cellular processes that are important for proper cellular function. For example, it is involved in the production of the molecule superoxide, which is a reactive oxygen species that can cause damage to cells if it is not properly managed. Superoxide can be produced by a variety of cellular processes, including the production of energy by cellular metabolism. In addition, MSRB1 is also involved in the production of the molecule dihydrolipoyl-CoA (DLC), which is a key component of the citric acid cycle.

The potential use of MSRB1 as a drug target is further enhanced by its location in the mitochondria. Mitochondria are organelles that are responsible for producing the majority of the energy that the body uses to function. Therefore, any drug that can effectively reduce the production or levels of methionine in the mitochondria could potentially be used to treat a variety of diseases. In addition, because mitochondria are also responsible for producing many of the compounds that are involved in the production of superoxide and DLC, any drug that can effectively reduce these compounds could potentially be used to treat a variety of diseases.

In conclusion, MSRB1 is a gene that encodes a protein located in the mitochondria that is involved in a critical cellular process called the detoxification of methionine. The production or levels of methionine can cause a variety of health problems, including damage to the liver, heart , and brain. As a result, MSRB1 has been identified as a potential drug target or biomarker for a variety of diseases. In addition to its role in the detoxification of methionine, MSRB1 is also involved in the production of many other cellular compounds that are important for proper cellular function. Therefore, any drug that can effectively reduce the production or levels of these compounds could potentially be used to treat a variety of diseases.

Protein Name: Methionine Sulfoxide Reductase B1

Functions: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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