SMO: Unlocking The Potential of A Protein Involved in Various Processes

Target Name: SMO

NCBI ID: G6608

Content of Review Report on SMO Target / Biomarker

SMO

SMO: Unlocking The Potential of A Protein Involved in Various Processes

SMO (frizzled family member 11) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and liver. It is a member of the SMO gene family, which is known for the production of stress-responsive proteins that play a role in stress responses and cellular signaling.

SMO has been shown to be involved in a number of different cellular processes, including cell signaling, DNA damage repair, and stress responses. It is also involved in the development and progression of a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key challenges in studying SMO is its high level of expression, which can make it difficult to study in a controlled and precise manner. However, researchers have been able to use a number of techniques to study SMO and its role in different cellular processes.

One of the main approaches used to study SMO is through the use of RNA interference (RNAi) technology. RNAi allows researchers to specifically target and knock down the expression of a particular gene, such as SMO, in order to study its effects on cellular processes and diseases.

Researchers have used RNAi to study the role of SMO in a number of different processes, including cell signaling, stress responses, and DNA damage repair. They have found that SMO plays a critical role in these processes and that its levels are often reduced in diseases caused by stress, such as cancer and neurodegenerative disorders.

Another approach used to study SMO is through the use of mass spectrometry (MS). MS allows researchers to identify and quantify the different proteins that are produced by a particular gene, including SMO. This can be a useful way to study the expression and function of SMO in different cellular processes and diseases.

Researchers have also used other techniques, such as live cell imaging and biochemical assays, to study the role of SMO in different cellular processes and diseases. These techniques allow researchers to see how SMO functions in different contexts and to study its effects on cellular processes in real-time.

Despite the many advances in the study of SMO, there is still much to be learned about its role in different cellular processes and diseases. For example, researchers are still working to fully understand the mechanisms by which SMO promotes stress responses and disease development.

In addition, there is a need for more research on the safety and effectiveness of SMO as a drug target. While SMO has been shown to be involved in a number of different cellular processes and diseases, it is not yet clear how it can be used to treat these conditions. Further research is needed to determine the full potential of SMO as a drug target and to develop safe and effective treatments.

In conclusion, SMO (frizzled family member 11) is a protein that is expressed in various tissues throughout the body and is involved in a number of different cellular processes and diseases. While much research has been done to study its role, there is still much to be learned about its mechanisms and potential uses as a drug target. Further research is needed to fully understand the role of SMO in different cellular processes and diseases and to develop safe and effective treatments.

Protein Name: Smoothened, Frizzled Class Receptor

Functions: G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling. Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched. When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity)

The "SMO Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SMO comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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