SNRPA1: A Potential Drug Target for Cancer (G6627)

Target Name: SNRPA1

NCBI ID: G6627

SNRPA1

SNRPA1: A Potential Drug Target for Cancer

SNRPA1 (RU2A_HUMAN), a protein that belongs to the nucleosome-remodeling complex (NRC), has been identified as a potential drug target or biomarker for various diseases, including cancer. Its functions and interactions with other proteins have been extensively studied, providing insights into its potential clinical applications.

The nucleosome is a protein complex that plays a critical role in the regulation of gene expression and DNA replication. It is composed of histone proteins, which are responsible for organizing DNA in a compact structure, and non-histone proteins, including SNRPA1. SNRPA1 is a 21-kDa protein that is expressed in various cell types, including human cells.

SNRPA1 functions as a nucleosome-remodeling complex protein, which means it helps to maintain the integrity and accessibility of the nucleosome. It does this by participating in the formation of the nucleosome and by modifying the composition of the nucleosome proteins. SNRPA1 has been shown to play a crucial role in the regulation of DNA replication, cell division, and chromosomal stability.

One of the key functions of SNRPA1 is its role in the regulation of DNA replication. SNRPA1 has been shown to interact with the DNA replication machinery, including the complex composed of the enzyme DNA polymerase I (DNA-P1) and the protein p53. DNA -P1 is responsible for copying the DNA template to the newly synthesized strand, while p53 plays a critical role in regulating the process.

SNRPA1 has been shown to play a role in the regulation of gene expression by affecting the accessibility of DNA-bound transcription factors. For example, it has been shown to interact with the protein Myc, which is a transcriptional regulator that plays a role in the regulation of various cellular processes, including cell growth, differentiation, and cancer progression.

SNRPA1 has also been shown to be involved in the regulation of chromatin remodeling, which is the process by which the DNA double helix is 鈥嬧?媡ransformed into a more compact form called chromatin. Chromatin remodeling is important for the regulation of gene expression and has been implicated in various diseases, including cancer.

In addition to its role in the regulation of DNA replication and chromatin remodeling, SNRPA1 has also been shown to be involved in the regulation of cell signaling pathways. For example, it has been shown to interact with the protein tyrosine kinase Fyn, which is involved in the regulation of various cellular processes, including cell growth, differentiation, and cancer progression.

SNRPA1 has also been shown to be involved in the regulation of cellular adhesion, which is the process by which cells stick together to form tissues and organs. This process is important for the development and maintenance of tissues and organs, and is implicated in various diseases , including cancer.

In conclusion, SNRPA1 is a protein that has important functions in the regulation of DNA replication, chromatin remodeling, cell signaling pathways, and cellular adhesion. Its potential as a drug target or biomarker makes it an attractive target for the development of new therapies for various diseases, including cancer. Further research is needed to fully understand the functions of SNRPA1 and its potential as a drug.

Protein Name: Small Nuclear Ribonucleoprotein Polypeptide A'

Functions: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:27035939). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128, PubMed:27035939)

The "SNRPA1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNRPA1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets