Socrs1: A Potential Drug Target and Biomarker (G8651)

Target Name: SOCS1

NCBI ID: G8651

SOCS1

Socrs1: A Potential Drug Target and Biomarker

Socs1, also known as SH2 protein 1, is a cytokine-inducible protein that plays a critical role in the immune system. It is a member of the superfamily of resource-sharing receptors and belongs to the receptor tyrosine receptor in the signal transduction pathway acid kinase (RTK) family. Socs1 plays an important role in various physiological processes, such as cell proliferation, differentiation and tumorigenesis. At the same time, Socs1 is also regarded as a potential drug target (or biomarker).

The protein encoded by the Socs1 gene is a 24kDa polypeptide that contains 4 domains: N-terminal 伪-helix, central 尾-page, C-terminal 伪-helix and intracellular region. The N-terminal 伪-helix is 鈥嬧?媡he most important domain in the Socs1 protein, and the 蔚 chain repeat domain (ERD) is considered to be the main domain for Socs1 to recognize ligands.

The function of Socs1 protein mainly depends on its binding to ligand. Socs1 protein binds to many different types of ligands in cells, including cytokines, growth factors, DNA-binding proteins, etc. The binding of these ligands to the Socs1 protein will lead to the activation of a series of signal transduction pathways, thereby affecting biological processes in cells.

The activation of Socs1 protein is closely related to the intracellular signal transduction pathway. In cells, Socs1 protein interacts with many signal transduction molecules, such as FAK, PI3K, MAPK, etc. These signal transduction molecules interact with the phosphorylation of Socs1 protein, causing changes in the activity of Socs1 protein, thus regulating intracellular biological processes.

The role of Socs1 protein in tumorigenesis has also been extensively studied. Many studies have shown that Socs1 protein plays a role in promoting tumorigenesis in a variety of tumors. For example, knockdown of Socs1 gene can significantly inhibit tumor growth, while overexpression of Socs1 protein can promote tumor progression. These findings provide an important theoretical basis for Socs1 protein as a tumor treatment target.

In addition, Socs1 protein also plays an important role in immune response. Socs1 protein can bind to many ligands on the surface of immune cells, such as PD-1, PD-L1, etc. The binding of these ligands to the Socs1 protein can activate the function of immune cells, thereby enhancing the effectiveness of the immune response. Therefore, Socs1 protein is also regarded as a potential immunotherapy target.

The study of Socs1 protein as a drug target or biomarker is of great significance. First, by studying the function and mechanism of Socs1 protein, we can gain an in-depth understanding of the biological process of cell signal transduction pathways. Secondly, the role of Socs1 protein in tumorigenesis and immune response provides important clues for drug development. Finally, Socs1 protein, as a potential drug target, can promote the process of drug development and provide new ideas for the treatment of various diseases.

In short, Socs1 protein is a protein with broad research prospects. Through in-depth study of the function and mechanism of Socs1 protein, we can provide an important theoretical basis for drug research and development and provide new ideas for the treatment of various diseases.

Protein Name: Suppressor Of Cytokine Signaling 1

Functions: Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480)

The "SOCS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SOCS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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