Target Name: SNX6
NCBI ID: G58533
Review Report on SNX6 Target / Biomarker Content of Review Report on SNX6 Target / Biomarker
SNX6
Other Name(s): OTTHUMP00000178808 | MSTP010 | Tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2 | TFAF2 | SNX6_HUMAN | Sorting nexin-6 isoform b | sorting nexin 6 | TRAF4-associated factor 2 | tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2 | Sorting nexin-6 | OTTHUMP00000178809 | Sorting nexin 6, transcript variant 2 | SNX6 variant 2 | Sorting nexin-6, N-terminally processed | MGC3157

SNX6: A Protein Involved in Brain Development, Function and Metabolism

SNX6, also known as OTTHUMP00000178808, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of proteins known as the IMP-1 (inositol-requiring protein 1) family, which is characterized by the presence of a specific domain called the Inositol-Binding protein (IBP) domain.

The IBP domain is a conserved region that is found in a variety of proteins, including SNX6. It is made up of a series of amino acids that are involved in the formation of a cation-lipped core, which is capable of binding to and interacting with various molecules. This core is thought to play a role in the regulation of various cellular processes, including intracellular signaling, metabolism, and stress response.

One of the unique features of SNX6 is its ability to interact with the protein p120GAP, which is a transcription factor that is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. The p120GAP-SNX6 interaction has been shown to play a role in the regulation of cellular processes that are important for brain development and function, such as the formation of new neurons, the regulation of neurotransmitter release, and the modulation of cellular signaling pathways.

Another interesting property of SNX6 is its ability to interact with the protein TRPV4, which is a receptor for the neurotransmitter acetylcholine. The TRPV4-SNX6 interaction is thought to play a role in the regulation of various physiological processes that are involved in neurotransmission, including the modulation of neural activity and the regulation of sensory perception.

In addition to its interactions with p120GAP and TRPV4, SNX6 has also been shown to interact with a variety of other proteins, including the protein STK12, which is involved in the regulation of cell growth and differentiation, and the protein FERMT1, which is involved in the regulation of cell division and fusion.

Given its unique combination of features, SNX6 has generated a lot of interest among researchers as a potential drug target or biomarker. Studies have shown that SNX6 is involved in a variety of cellular processes that are important for brain development and function, including the regulation of neurotransmission, the formation of new neurons, and the regulation of cellular signaling pathways.

In addition to its role in brain development and function, SNX6 has also been shown to be involved in the regulation of various metabolic processes, including the regulation of insulin sensitivity and the modulation of glucose metabolism. This suggests that SNX6 may be a useful target for interventions aimed at improving metabolic health and reducing the risk of certain diseases, such as diabetes.

Another potential application of SNX6 is its role in the regulation of cellular signaling pathways. Many diseases, including cancer, are thought to be caused by the disruption of normal cellular signaling pathways. By targeting SNX6 and its associated signaling pathways, researchers may be able to develop new treatments for a variety of diseases.

In conclusion, SNX6 is a protein that is expressed in various tissues of the body and is involved in a variety of cellular processes that are important for brain development and function, including the regulation of neurotransmission, the formation of new neurons, and the regulation of cellular signaling pathways. Its unique combination of features, including its ability to interact with p120GAP and TRPV4, as well as its ability to interact with a variety of other proteins, makes SNX6 an attractive target for research and development of new treatments for a variety of diseases.

Protein Name: Sorting Nexin 6

Functions: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable)

The "SNX6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNX6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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