STK3: Potential Drug Target and Biomarker for Various Diseases

Target Name: STK3

NCBI ID: G6788

STK3

STK3: Potential Drug Target and Biomarker for Various Diseases

STK3 (Sud alcalase 3) is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the Sud alkaline 3 (SPH) gene family, which encodes a group of enzymes that belong to the pH 7.0-phosphatidylinositol (PI) signal transduction pathway. STK3 is also known as MST-2, and it is a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The STK3 gene was first identified in 2008 based on the analysis of genomic DNA samples from various human tissues. The gene is located on chromosome 1p36 and encodes a protein that has a calculated molecular weight of 41 kDa. STK3 is a single gene that encodes a protein that is expressed in various tissues throughout the body, including the brain, pancreas, muscle, and placenta.

The STK3 protein is involved in a variety of cellular processes that are important for cell survival and proliferation. One of the key functions of STK3 is that it is a critical regulator of the PI signaling pathway, which is a critical pathway that regulates various cellular processes , including cell growth, differentiation, and survival. The PI signaling pathway is a highly conserved signaling pathway that is involved in the regulation of various cellular processes, including cell survival, angiogenesis, and inflammation.

STK3 is a key enzyme in the PI signaling pathway that is involved in the regulation of various cellular processes. It is a critical regulator of cell growth and differentiation and has been implicated in the development and progression of various diseases. For example, STK3 has been shown to be involved in the regulation of cancer cell growth and has been used as a potential drug target for cancer therapy.

In addition to its role in the PI signaling pathway, STK3 is also involved in the regulation of various cellular processes that are important for cell survival and proliferation. It is a critical regulator of cell adhesion, which is the process by which cells stick together and form tissues. STK3 is also involved in the regulation of cell migration, which is the process by which cells move from one location to another in the body.

STK3 has also been shown to be involved in the regulation of various cellular processes that are important for neurodegenerative diseases. For example, STK3 has been shown to be involved in the regulation of neurodegenerate diseases, including Alzheimer's disease and Parkinson's disease. It is possible that STK3 may be a potential drug target for these diseases and may be used in the development of new therapies for these conditions.

In addition to its role in the PI signaling pathway and its involvement in the regulation of various cellular processes, STK3 is also a potential biomarker for various diseases. For example, STK3 has been shown to be involved in the regulation of inflammation and has been used as a potential biomarker for various inflammatory diseases, including rheumatoid arthritis and colitis.

In conclusion, STK3 is a protein that is involved in a variety of cellular processes that are important for cell survival and proliferation. It is a key regulator of the PI signaling pathway and has been implicated in the development and progression of various diseases, including cancer , neurodegenerative diseases, and autoimmune disorders. As a potential drug target and biomarker, STK3 is a promising target for the development of new therapies for these conditions. Further research is needed to fully understand the role of STK3 in these processes and to develop new treatments based on this protein.

Protein Name: Serine/threonine Kinase 3

Functions: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38

The "STK3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about STK3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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