SMMP1: A Mitochondrial Protein with Potential as A Drug Target

Target Name: STMP1

NCBI ID: G647087

STMP1

SMMP1: A Mitochondrial Protein with Potential as A Drug Target

Short Transmembrane Mitochondrial Protein 1 (SMMP1) is a protein that is expressed in the mitochondria, which are organelles that are responsible for generating energy in the cell through a process called cellular respiration. SMMP1 is a member of the Mitochondrial Protein Family 1, which is a group of proteins that are involved in various cellular processes in the mitochondria.

SMMP1 is a transmembrane protein, which means that it spans the inner and outer membranes of the mitochondria. It is made up of 116 amino acids and has a calculated molecular weight of 13.9 kDa. The protein has a unique structure, with a catalytic domain that is located at the cytoplasmic side of the membrane and a transmembrane region that is responsible for its unique function.

SMMP1 is involved in a number of different cellular processes in the mitochondria, including the citric acid cycle, the electron transport chain, and the transition electron transfer. It is also involved in the regulation of mitochondrial fusion and the dynamics of the mitochondrial genome.

SMMP1 has been identified as a potential drug target for a number of diseases, including cancer, neurodegenerative diseases, and cardiovascular disease. Its unique structure and various functions make it an attractive target for drug development, as researchers are working to develop compounds that can inhibit SMMP1 activity and treat a range of diseases.

One way that researchers are studying SMMP1 is to use techniques such as mass spectrometry, which allows them to identify and quantify the unique amino acids that make up the protein. This has helped researchers to gain a better understanding of the structure and function of SMMP1, as well as the potential targets for drug development.

Another approach that researchers are using to study SMMP1 is to use RNA interference, which allows them to knockdown the expression of specific genes in the cells and to see how this affects the protein's levels and its function. This has been a powerful tool for studying the role of SMMP1 in various cellular processes, including the citric acid cycle and the electron transport chain.

SMMP1 is also being studied as a potential biomarker for a number of diseases. Its expression has been shown to be elevated in a range of cancer types, including breast, ovarian, and colorectal cancer. This makes it an potential target for cancer therapies that target mitochondrial processes.

In addition to its potential as a drug target and biomarker, SMMP1 is also of interest to researchers as a potential therapeutic agent for a number of other conditions. For example, SMMP1 has been shown to be involved in the regulation of cellular processes that are important for brain development and function, such as the transport of oxygen and nutrients to the brain cells. This makes it an potential target for therapies that are aimed at improving brain health and function.

Overall, SMMP1 is a protein that is of great interest to researchers due to its unique structure and function in the mitochondria. Its potential as a drug target and biomarker make it an attractive target for further study, and its role in various cellular processes makes it an important player in the field of cellular biology.

Protein Name: Short Transmembrane Mitochondrial Protein 1

Functions: Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly (PubMed:35450818). Required for the formation of mitochondrial supercomplexes (SCs) (PubMed:35450818). Also required for the activation of the NLRP3 inflammasome (By similarity)

The "STMP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about STMP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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