Targeting STXBP4 for Human Health (G252983)

Target Name: STXBP4

NCBI ID: G252983

STXBP4

Targeting STXBP4 for Human Health

STXBP4 (STXB4_HUMAN), also known as human STXBP4, is a protein that is expressed in various tissues of the human body, including the brain, spinal cord, and peripheral nerves. It is a member of the STX family, which includes STXA1, STXA2 , STXA3, and STXA4, and is responsible for the production of a unique type of lipid called 尾-hydroxy-cholesterol (尾-h cholesterol).

The 尾-h cholesterol is a crucial component of cell membrane structure and is involved in various physiological processes, including the absorption of fat into the body and the production of hormones. It is also a risk factor for the development of various diseases, including cardiovascular disease and metabolic disorders.

Research has shown that high levels of 尾-h cholesterol are associated with an increased risk of developing certain diseases, such as metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and cognitive impairment. Therefore, targeting STXBP4 as a drug target or biomarker may have significant implications for the treatment of these diseases.

One potential approach to targeting STXBP4 is through the use of statins, which are commonly used to lower cholesterol levels. Statins work by inhibiting the production of 尾-h cholesterol in the liver, which in turn leads to a decrease in the levels of 尾- h cholesterol in the body. However, this approach may not be effective in all cases, as some individuals may have STXBP4 gene variants that result in decreased levels of 尾-h cholesterol production.

Another potential approach to targeting STXBP4 is through the use of drugs that increase the levels of 尾-h cholesterol in the body. For example, some studies have shown that treatments that increase the levels of 尾-h cholesterol, such as ezetimibe, may have beneficial effects on various tissues, including the brain and spinal cord.

In addition to its potential use as a drug target or biomarker, STXBP4 is also a promising candidate for use as a diagnostic tool for certain diseases. For example, some studies have shown that individuals with certain genetic variants, such as those found in the STXBP4 gene, may have an increased risk of developing certain diseases, such as NAFLD. Therefore, STXBP4 may be used as a diagnostic tool to identify individuals at risk for these diseases.

Overall, STXBP4 is a protein that is expressed in various tissues of the human body and is involved in the production of 尾-h cholesterol. High levels of 尾-h cholesterol are associated with an increased risk of developing various diseases, and targeting STXBP4 as a drug target or biomarker may have significant implications for the treatment of these diseases. Further research is needed to fully understand the role of STXBP4 in human health and to develop effective treatments.

Protein Name: Syntaxin Binding Protein 4

Functions: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity)

The "STXBP4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about STXBP4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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