STXBP1: Syntaxin-Binding Protein Regulates Microtubule Dynamics

Target Name: STXBP1

NCBI ID: G6812

STXBP1

STXBP1: Syntaxin-Binding Protein Regulates Microtubule Dynamics

Syntaxin-binding protein 1 (ISOform A), also known as STXBP1, is a protein that is expressed in various tissues throughout the body. It is a key protein that is involved in the regulation of syntaxin, a protein that is involved in the structure and function of microtubules in cells. Syntaxin is composed of two isoforms, ISOform A and ISOform B, and each isoform has a different function in the cell. ISOform A is the most abundant isoform, and it is involved in the regulation of microtubule dynamics, while ISOform B is involved in the regulation of microtubule stability.

STXBP1 is a 21-kDa protein that is expressed in various tissues, including brain, heart, and skeletal muscles. It is primarily localized to the endoplasmic reticulum (ER), a system of organelles that transports proteins from the cytoplasm to the plasma membrane. STXBP1 is also expressed in the nuclei of various cell types, including muscle and neural cells.

One of the unique features of STXBP1 is its ability to interact with syntaxin. Syntaxin is a protein that is involved in the regulation of microtubule dynamics, and it is composed of two isoforms, ISOform A and ISOform B. ISOform A is the most abundant isoform, and it is involved in the regulation of microtubule dynamics, while ISOform B is involved in the regulation of microtubule stability. STXBP1 has been shown to interact with both ISOform A and ISOform B, and these interactions are important for the regulation of microtubule dynamics.

In addition to its role in the regulation of microtubule dynamics, STXBP1 is also involved in the regulation of various cellular processes, including cell signaling, cell adhesion, and cell migration. It is part of a signaling pathway that is involved in the regulation of muscle growth and differentiation, and it has been shown to play a role in the regulation of neural stem cell proliferation and differentiation.

STXBP1 is also of interest as a potential drug target or biomarker. Its involvement in the regulation of microtubule dynamics and its ability to interact with syntaxin make it a potential target for small molecules that can modulate microtubule dynamics. This has led to a growing interest in the development of compounds that can inhibit the activity of STXBP1 and modulate microtubule dynamics.

In addition to its potential as a drug target, STXBP1 is also of interest as a biomarker. Its expression in various tissues and its ability to interact with syntaxin make it a potential marker for the diagnosis and prognosis of various diseases. For example, STXBP1 has been shown to be downregulated in various diseases, including cancer, and its levels have been shown to be elevated in diseases, such as neurodegenerative diseases.

Overall, STXBP1 is a protein that is involved in the regulation of various cellular processes and its expression and activity are regulated by various factors. Its role in the regulation of microtubule dynamics and its ability to interact with syntaxin make it a potential target for small molecules and a biomarker for various diseases. Further research is needed to fully understand the role of STXBP1 in the regulation of microtubule dynamics and its potential as a drug target and biomarker.

Protein Name: Syntaxin Binding Protein 1

Functions: Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synapic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions

The "STXBP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about STXBP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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