STT3A Variant 1: A Potential Drug Target for Ischemic Stroke (G3703)

Target Name: STT3A

NCBI ID: G3703

STT3A

STT3A Variant 1: A Potential Drug Target for Ischemic Stroke

Stroke is a leading cause of death worldwide, affecting over 470 million people every year. The most common type of stroke is ischemic stroke, which occurs when the blood flow to the brain is blocked or reduced. The most common cause of ischemic stroke is the buildup of plaque in the blood vessels that supply the brain. This type of stroke is often treated with drugs that help to dissolve the plaque and restore blood flow.

The STT3A variant 1 is a protein that is expressed in the brain and has been shown to be involved in the development and progression of ischemic stroke. It is a potential drug target for stroke treatment.

The STT3A protein

STT3A is a member of the spectin domain family of proteins, which are a type of transmembrane protein that contains a spectin gene. The spectin gene is a non-coding RNA molecule that is translated into a protein by a process called splicing. The STT3A protein is a single gene that encodes a protein with 199 amino acid residues.

The STT3A protein is expressed in the brain and is involved in various cellular processes, including cell signaling, neurotransmitter signaling, and inflammation. It is a potent inhibitor of the protein Phosphatidylserine, which is an essential component of the cell membrane that helps to maintain the brain's barrier. The Phosphatidylserine inhibitor STT3A has been shown to protect against ischemic stroke in animal models.

The STT3A variant 1

The STT3A gene has several variants, including STT3A variant 1 and STT3A variant 2. STT3A variant 1 is a more stable and potent inhibitor of Phosphatidylserine compared to the other variants. This variant has been shown to be involved in the development and progression of ischemic stroke in animal models.

The potential implications of STT3A variant 1 as a drug target are significant. If STT3A variant 1 can be successfully targeted and inhibited, it may be a useful treatment for ischemic stroke. This could have a significant impact on stroke treatment and management.

The development of STT3A variant 1 as a drug target

The development of STT3A variant 1 as a drug target for stroke treatment began with the identification of its potential therapeutic benefits. Studies have shown that STT3A variant 1 has been shown to protect against ischemic stroke in animal models.

The first study to identify the potential benefits of STT3A variant 1 was published in the journal Nature Communications in 2012. In this study, researchers found that STT3A variant 1 was a potent inhibitor of Phosphatidylserine and that this inhibition protected against ischemic stroke in animal models.

Subsequent studies have confirmed the potential benefits of STT3A variant 1 as an ischemic stroke treatment. In a study published in the journal Stroke in 2016, researchers found that administration of STT3A variant 1 to mice after ischemia-induced stroke resulted in improved neurological function and reduced inflammation compared to a control group.

Another study published in the journal Brain in 2019 found that STT3A variant 1 was overexpressed in the brains of individuals with Alzheimer's disease, and that this overexpression was associated with increased Phosphatidylserine levels. The researchers suggested that STT3A variant 1 may be a potential therapeutic target for Alzheimer's disease.

The potential clinical applications of STT3A variant 1 are significant. If its potential benefits can be confirmed, it may be a useful addition to the treatment options available for ischemic stroke.

Conclusion

STT3A variant 1 is a protein that has been shown to be involved in the development and progression of ischemic stroke. The potential clinical applications of STT3A variant 1 are significant, as it has been shown to be a potent inhibitor of Phosphatidylserine and to protect against ischemic stroke in animal models. Further studies are needed to confirm its potential as a drug target for stroke treatment.

Protein Name: STT3 Oligosaccharyltransferase Complex Catalytic Subunit A

Functions: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667, PubMed:34653363). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A (PubMed:19167329)

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