STOML2: A Potential Drug Target and Biomarker (G30968)

Target Name: STOML2

NCBI ID: G30968

STOML2

STOML2: A Potential Drug Target and Biomarker

Stroke is a leading cause of morbidity and mortality worldwide, affecting over 47 million people each year. The underlying cause of stroke is the disruption of blood flow to the brain, which can result in damage to neural cells and potentially life-threatening complications. Understanding the molecular mechanisms underlying stroke is critical for the development of effective treatments. One potential drug target in this context is STOML2, a gene that has recently been identified as a promising biomarker and potential drug target for stroke.

STOML2: The Undiscovered Genetic Risk Factors

Stroke is a complex disease that has been associated with a range of genetic and environmental factors. While several risk factors for stroke have been identified, the underlying genetic mechanisms that contribute to the disease remain largely unexplored. The STOML2 gene, which encodes a protein involved in the regulation of blood-brain barrier (BBB) permeability, is one of these genetic factors that has recently been identified as a potential drug target and biomarker for stroke.

The Disruption of Blood-Brain Barrier (BBB)

The BBB is a specialized barrier that separates the brain from the surrounding bloodstream. It plays a crucial role in maintaining the integrity of the brain and preventing harmful substances from entering the brain. However, in the case of stroke, the disruption of the BBB has been implicated in the increased risk of neural damage and stroke.

STOML2: The Potential Drug Target

The STOML2 gene encodes a protein that is involved in the regulation of the BBB. Specifically, it is a transmembrane protein that is expressed in the endothelial cells of the brain blood vessels. Studies have shown that the expression of STOML2 is increased in the brains of individuals with risk factors for stroke, such as hypertension, diabetes, and family history of stroke.

In addition, STOML2 has been shown to play a role in the regulation of the production of other proteins involved in theBBB. These proteins, including tight junction (TJ) proteins, are responsible for maintaining the integrity of the BBB and may be involved in the disruption of blood flow to the brain that is associated with stroke.

The Potential Role of STOML2 as a Biomarker

The identification of STOML2 as a potential drug target and biomarker for stroke is based on several studies that have demonstrated its involvement in the regulation of the BBB and its potential role in the development of stroke.

First, a study by researchers at the University of California, San Diego found that individuals with the genetic variation in STOML2 were more likely to have a history of stroke than those without the variation. This suggests that STOML2 may be a promising biomarker for stroke, particularly in individuals with a family history of the disease.

Second, studies have shown that the expression of STOML2 is increased in the brains of individuals with risk factors for stroke, such as hypertension and diabetes. This suggests that STOML2 may be a potential drug target for stroke, particularly in individuals with these risk factors.

Third, researchers have shown that the disruption of the BBB is associated with an increased risk of stroke. The STOML2 protein has been shown to play a role in the regulation of the production of other proteins involved in the BBB, which suggests that it may be involved in the disruption of blood flow to the brain that is associated with stroke.

The Potential clinical Applications

The identification of STOML2 as a potential drug target and biomarker for stroke has significant implications for the development of new treatments for this debilitating disease. If STOML2 is found to be a reliable biomarker for stroke, it may be used as a target for drug development to prevent or

Protein Name: Stomatin Like 2

Functions: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation

The "STOML2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about STOML2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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