BTK: A Potential Drug Target for Cancer (G695)

Target Name: BTK

NCBI ID: G695

Content of Review Report on BTK Target / Biomarker

BTK

BTK: A Potential Drug Target for Cancer

BTK (Bcr-Abl kinase) is a protein that is expressed in various tissues of the human body, including the brain, and plays a crucial role in the development and progression of many types of cancer. The BTK gene has been identified as a potential drug target for various diseases, including leukemia, lymphoma, and multiple myeloma.

The BTK gene was first identified in the 1990s as a gene that was highly expressed in human leukemia cells. Studies have since shown that BTK is involved in the regulation of many cellular processes that are important for cancer growth and progression. BTK has been shown to play a role in the development and progression of both acute and chronic myeloid leukemias, as well as other types of cancer.

One of the main functions of BTK is its role in the regulation of the cell cycle. BTK is a transcription factor that can bind to specific DNA sequences and regulate the expression of genes that are involved in the cell cycle. This function of BTK is critical for the development and progression of cancer because it allows cells to multiply and divide uncontrollably.

In addition to its role in cell cycle regulation, BTK is also involved in the regulation of many other cellular processes that are important for cancer growth and progression. For example, BTK has been shown to play a role in the regulation of apoptosis, which is the process by which cells die and are removed from the body.

BTK has also been shown to play a role in the regulation of angiogenesis, which is the process by which new blood vessels form in the body. This function of BTK is important for the development of many types of cancer because it allows cancer cells to access the oxygen and nutrients that they need to grow and survive.

BTK is also involved in the regulation of immune response, which is an important function for fighting off cancer cells. BTK has been shown to play a role in the development and regulation of T cells, which are a key part of the immune system.

In addition to its role in cancer growth and progression, BTK is also involved in the regulation of many other cellular processes that are important for normal cellular function. For example, BTK is involved in the regulation of cell adhesion, which is the process by which cells stick together and form tissues. This function of BTK is important for the development and maintenance of tissues and organs.

BTK is also involved in the regulation of the cytoskeleton, which is the structure that makes up the cell nucleus. This function of BTK is important for the proper functioning of the cell and for the development and progression of cancer.

In conclusion, BTK is a protein that plays a crucial role in the development and progression of many types of cancer. The BTK gene has been identified as a potential drug target for various diseases, including leukemia, lymphoma, and multiple myeloma. Further research is needed to fully understand the role of BTK in cancer and to develop effective treatments for these diseases.

Protein Name: Bruton Tyrosine Kinase

Functions: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072)

The "BTK Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BTK comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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