Unknown Full-Thrombin Activator 1: A Potential Drug Target for Thromboembolism

Target Name: UFD1

NCBI ID: G7353

UFD1

Unknown Full-Thrombin Activator 1: A Potential Drug Target for Thromboembolism

UFD1 (Unknown Full-Thrombin Activator 1) is a protein that is expressed in various tissues throughout the body. It is a key player in the regulation of blood clotting and has been identified as a potential drug target in the field of thromboembolism.

Thromboembolism is a serious condition that can be caused by the formation of blood clots in the body. These clots can block blood vessels, causing a range of symptoms, including leg pain, difficulty breathing, and even death. UFD1 plays a crucial role in the regulation of blood clotting by activating the protein thrombin.

Thrombin is a protein that is expressed in various tissues throughout the body, including the liver, spleen, heart, and blood vessels. It is a key player in the regulation of blood clotting by activating the protein plasmin-1 (F1) and thrombin-activated plasmin (TAF). UFD1 has been shown to play a role in the regulation of thrombin activity by activating TAF.

In addition to its role in thrombin regulation, UFD1 has also been shown to play a role in the regulation of platelet function. Platelets are a type of blood cell that play a critical role in blood clot formation. by activating the protein P1G120, which is involved in the regulation of platelet activation and aggregation.

The potential drug target status of UFD1 is due to its involvement in the regulation of thrombin and platelet function, as well as its role in the regulation of blood clotting. This suggests that UFD1 may be a useful target for the treatment of thromboembolic disorders.

In conclusion, UFD1 is a protein that is expressed in various tissues throughout the body and plays a crucial role in the regulation of blood clotting. Its potential as a drug target makes it an attractive target for the development of new treatments for thromboembolic disorders. Further research is needed to fully understand the role of UFD1 in the regulation of blood clotting and to develop effective treatments for thromboembolic disorders.

Protein Name: Ubiquitin Recognition Factor In ER Associated Degradation 1

Functions: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729)

The "UFD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UFD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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