PRRT1: A Potential Drug Target and Biomarker (G80863)

Target Name: PRRT1

NCBI ID: G80863

PRRT1

PRRT1: A Potential Drug Target and Biomarker

Proline-rich transmembrane protein 1 (ProTMP1, also known as ISOFORM 1) is a protein that is expressed in various cell types of the human body, including epithelial, endothelial, and peritoneal cells. It is a member of the PRT family of transmembrane proteins, which are involved in the regulation of cell signaling pathways. PRT1 is characterized by its unique proline-rich sequence, which is found in a uniqueisoform 1 isoform.

The PRT family of proteins plays a crucial role in the regulation of cell signaling pathways, including cell adhesion, migration, and invasion. PRT1 is involved in these processes by interacting with various signaling molecules, including TGF-β1, Wnt, and Notch. It is also involved in the regulation of cell apoptosis, which is a critical mechanism for cell death and turnover.

PRT1 has also been shown to be involved in the regulation of cell cycle progression, with studies indicating that it plays a role in the G1/S transition. It has also been shown to interact with the protein p21, which is a hallmark of the G1/S transition.

In addition to its role in cell signaling pathways, PRT1 has also been shown to be involved in the regulation of cell adhesion and migration. Studies have shown that PRT1 interacts with the protein E-cadherin, which is involved in cell-cell adhesion, and that this interaction is critical for the regulation of cell migration.

Furthermore, PRT1 has been shown to play a role in the regulation of cell apoptosis. Studies have shown that PRT1 interacts with the protein Bcl-2, which is a protein that can induce apoptosis in cells. This interaction between PRT1 and Bcl-2 suggests that PRT1 may be a potential drug target for the treatment of apoptosis-related diseases.

In conclusion, PRT1 is a unique and highly characterized protein that is involved in the regulation of various cell signaling pathways. Its unique proline-rich sequence and its involvement in cell adhesion, migration, and apoptosis make it an attractive potential drug target. Further research is needed to fully understand the role of PRT1 in cell signaling pathways and its potential as a drug target.

Protein Name: Proline Rich Transmembrane Protein 1

Functions: Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression

The "PRRT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PRRT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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