PRSS36: A Potential Drug Target and Biomarker (G146547)

Target Name: PRSS36

NCBI ID: G146547

PRSS36

PRSS36: A Potential Drug Target and Biomarker

Protease serine 36 (PRSS36) is a protein that is expressed in various tissues throughout the body, including the liver, pancreas, and blood cells. It is a member of the serine proteases family 36 and is involved in the regulation of various cellular processes. PRSS36 has been identified as a potential drug target and biomarker due to its unique structure, function, and potential therapeutic applications.

The Serine Proteases Family 36

Serine proteases are a group of enzymes that belong to the serine proteases family 36. This family of enzymes is responsible for the hydrolysis of specific amino acids, which is a critical process in the regulation of various cellular processes. The serine proteases are classified based on their catalytic mechanism, substrate specificity, and molecular structure. PRSS36 is a member of the family 36, which is characterized by the presence of a specific catalytic site, known as the 尾-sheet, and a hydrophobic catalytic core.

PRSS36 Structure and Function

PRSS36 is a 17-kDa protein that contains 156 amino acid residues. It has a unique 3D structure, with a catalytic site that is located at the center of the protein and a hydrophobic catalytic core that is located at the peripheral side. The 尾-sheet, which is a hallmark feature of the serine proteases, is located at the side of the protein and is responsible for the formation of the catalytic site.

PRSS36 is involved in the regulation of various cellular processes, including cell signaling, inflammation, and tissue repair. It has been shown to play a role in the regulation of cell proliferation, differentiation, and apoptosis. PRSS36 has also been shown to be involved in the regulation of inflammation and tissue repair.

PRSS36 as a Potential Drug Target

PRSS36 has been identified as a potential drug target due to its unique structure and function. The catalytic site on PRSS36 makes it a promising target for small molecules that can modulate its activity. Additionally, the hydrophobic catalytic core of PRSS36 makes it difficult for water-soluble compounds to interact with the protein, which may limit its efficacy as a drug.

PRSS36 has been shown to interact with various small molecules, including inhibitors of the proteasome and inhibitors of the DNA-protein binding. Additionally, PRSS36 has been shown to interact with antibodies that are capable of targeting the protein. These interactions suggest that PRSS36 may be an effective drug target for a variety of diseases.

PRSS36 as a Biomarker

PRSS36 has also been identified as a potential biomarker due to its unique structure and function. The catalytic site on PRSS36 makes it a potential target for diagnostic agents that can react with the protein. Additionally, the hydrophobic catalytic core of PRSS36 makes it difficult for water-soluble compounds to interact with the protein, which may limit its efficacy as a diagnostic agent.

PRSS36 has been shown to be expressed in various tissues and has been detected using techniques such as Western blotting and immunofluorescence. Additionally, the protein has been shown to be stable in various cellular and biological samples, which suggests that it may be a suitable biomarker for a variety of applications.

Conclusion

PRSS36 is a unique protein that is expressed in various tissues throughout the body and has been shown to play a role in the regulation of various cellular processes. Its catalytic site and hydrophobic catalytic core make it a potential target for small molecules and diagnostic agents. Additionally, PRSS36 has been identified as a potential drug target and biomarker, which suggests that it may have a

Protein Name: Serine Protease 36

Functions: Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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