PRSS37: A Potential Drug Target and Biomarker for Serine Protease 37

Target Name: PRSS37

NCBI ID: G136242

PRSS37

PRSS37: A Potential Drug Target and Biomarker for Serine Protease 37

Abstract:

Serine protease 37 (PRSS37) is a highly conserved protein that plays a crucial role in various cellular processes. The primary function of PRSS37 is to regulate the proteasome, which is responsible for degrading proteins. PRSS37 plays a key role in biological processes such as apoptosis, cell cycle regulation, immune response, and metabolic regulation. However, abnormal PRSS37 expression levels are closely related to the occurrence and development of various diseases. Currently, research is mainly focused on finding drug targets and biomarkers related to PRSS37. This article focuses on the structure, function, regulatory mechanism and possible targets of PRSS37, and discusses the potential and challenges of PRSS37 as a drug target or biomarker.

1. Structure and function

PRSS37 is a 12kDa protein that belongs to the serine protease family. Its N-terminus is rich in lysine, which can form disulfide bonds with other proteins and is highly specific. PRSS37 exerts hydrolase activity in cells and is responsible for degrading substrates, such as extracellular matrix proteins, cell membrane proteins, nuclear proteins, etc. This function allows PRSS37 to play an important role in cell cycle, apoptosis, immune response, cell metabolism and other processes. The activity of PRSS37 can be inhibited by a variety of regulators, such as inhibitors of the proteasome, inhibitors of PRSS37 itself, etc..

2. Control mechanism

The activity of PRSS37 is affected by a variety of regulatory mechanisms, including DNA damage repair, gene expression regulation, protein modification, etc. Studies have found that the activity of PRSS37 is regulated by endogenous and exogenous DNA damage repair pathways. DNA damage repair pathways include homologous recombination pathways, double-strand break repair pathways, etc., which can repair functional damage of PRSS37. In addition, the expression of PRSS37 is regulated by a variety of transcription factors and regulators, such as the promoter enhancer of PRSS37, the RNA binding protein of PRSS37, etc. These transcription factors and regulators can affect the activity of PRSS37 by binding to specific regions of PRSS37.

3. Target point

PRSS37 plays an important role in a variety of diseases, such as tumors, neurodegenerative diseases, immune response, etc. For functional impairment of PRSS37, researchers have discovered multiple possible drug targets. First, the activity of PRSS37 can inhibit tumor growth by inhibiting protease activity. For example, studies have found that inhibiting the activity of PRSS37 can significantly inhibit the proliferation and growth of tumor cells. Secondly, PRSS37 plays an important role in neurodegenerative diseases. Studies have found that the activity of PRSS37 is closely related to the occurrence and development of neurodegenerative diseases and may be a potential biomarker and therapeutic target. In addition, PRSS37 plays an important role in immune response. Studies have found that the activity of PRSS37 can affect the function of immune cells and participate in the regulation of immune responses.

4. Challenges and the future

Although research on PRSS37 has made some progress in recent years, there are still challenges in the clinical application of PRSS37 as a drug target or biomarker. First, the mechanism of action of PRSS37 is still not completely clear and requires further study. Secondly, the relationship between the biological characteristics of PRSS37 and human diseases still needs to be further studied. Finally, the clinical application of PRSS37 is still in the exploratory stage and further relevant research is needed.

in conclusion:

PRSS37 is an important serine protease that plays a key role in apoptosis, cell cycle regulation, immune response, metabolic regulation and other processes. Currently, research is mainly focused on finding drug targets and biomarkers related to PRSS37. Although some progress has been made in recent years, the clinical application of PRSS37 as a drug target or biomarker still faces challenges. Future research should focus on in-depth study of the mechanism of action of PRSS37, reveal its association with diseases, and lay the foundation for the clinical application of PRSS37.

Protein Name: Serine Protease 37

Functions: Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system (PubMed:27649891)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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