PSMB10: A Promising Drug Target and Biomarker for Proteasome-Mediated Diseases

Target Name: PSMB10

NCBI ID: G5699

PSMB10

PSMB10: A Promising Drug Target and Biomarker for Proteasome-Mediated Diseases

Proteasomes are large protein structures that play a central role in regulating various cellular processes. They are composed of a 20S subunit尾10, which is a key component of the proteasome machinery. The 20S subunit尾10 is involved in the sorting and degradation of various protein species, and is thus, a crucial protein for cellular homeostasis. Abnormalities in the 20S subunit尾10 have been implicated in various diseases, including cancer, neurodegenerative disorders, and systemic inflammation. As a result, targeting this protein has become an attractive research topic in recent years.

PSMB10: A Potential Drug Target

The 20S subunit尾10 is a well-established drug target for small molecules. various studies have shown that inhibitors of 20S subunit尾10 can effectively inhibit protein degradation and cell growth, leading to increased protein levels and potentially beneficial effects on various cellular processes. One of the most promising 20S subunit尾10 inhibitors is PSMB10, a small molecule that was identified as a potential drug target for the treatment of various diseases.

PSMB10 is a synthetic compound that is derived from the natural compound pterostilbene, which is a non-coding RNA molecule. Pterostilbene has been shown to have various biological activities, including the inhibition of protein degradation and the inhibition of cell growth. By modifying the 20S subunit尾10, Pterostilbene has been shown to induce the expression of anti-inflammatory and anti-cancer genes, and to inhibit the expression of genes involved in cell growth and differentiation.

PSMB10 works by binding to the 20S subunit尾10 and interacting with its active site. This interaction causes a conformational change in the 20S subunit尾10, leading to the inhibition of protein degradation and the inhibition of cell growth. Pterostilbene has been shown to be effective in a variety of cellular models, including cancer, neurodegenerative disorders, and systemic inflammation.

PSMB10 is a small molecule that can be easily synthesized and has relatively low toxicity. Its effects on cellular processes are also reversible, which makes it an attractive drug candidate for the treatment of various diseases.

PSMB10 as a Biomarker

PSMB10 not only has potential as a drug target, but it also has the potential to serve as a biomarker for various diseases. The 20S subunit尾10 is involved in the sorting and degradation of various proteins, including cancer proteins. Therefore, the expression of 20S subunit尾10 is often used as a biomarker for cancer diagnosis and treatment.

PSMB10 has been shown to inhibit the expression of genes involved in cancer cell growth and differentiation, including genes involved in the development of neurodegenerative disorders. This suggests that Pterostilbene may have the potential to serve as a biomarker for the treatment of neurodegenerative disorders.

PSMB10 has also been shown to inhibit the expression of genes involved in inflammation. This suggests that Pterostilbene may have the potential to serve as a biomarker for the treatment of inflammatory diseases.

Conclusion

PSMB10 is a small molecule that has the potential to serve as a drug target and biomarker for various diseases. Its effects on cellular processes are also reversible, which makes it an attractive drug candidate for the treatment of various diseases. Further studies are needed to confirm its potential as a drug target and biomarker, and to determine its safety and efficacy in clinical trials.

Protein Name: Proteasome 20S Subunit Beta 10

Functions: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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