PSMB1: A Potential Drug Target and Biomarker for Proteasome-Mediated Diseases

Target Name: PSMB1

NCBI ID: G5689

PSMB1

PSMB1: A Potential Drug Target and Biomarker for Proteasome-Mediated Diseases

Introduction

Proteasomes, also known as proteasomes or peptidyl-prolyl bodies, are a type of protein complex that plays a crucial role in protein degradation in cells. These structures consist of a core of amino acids that is surrounded by a series of nested beta-helices, which form a framework for the recognition and cleavage of specific peptides. One of the key proteins involved in this process is PSMB1, also known as proteasome (prosome, macropain) subunit, beta type, 1.

PSMB1 is a 17-kDa protein that is expressed in most tissues of the body. It is highly conserved across species, and its only conserved amino acid sequence is N-Glu-Arg-Asp-Glu-Asp-Glu-Asp-Glu. PSMB1 is a key component of the proteasome complex, where it functions as a structural protein that forms the base of the nested beta-helices. This structural role is essential for the efficient recognition and cleavage of foreign peptides by the proteasome.

PSMB1 has been implicated in a wide range of diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. Its potential as a drug target or biomarker makes it an attractive target for researchers to study. In this article, we will explore the biology of PSMB1 and its potential as a drug target.

The Biology of PSMB1

PSMB1 is a 17-kDa protein that is expressed in most tissues of the body. It is highly conserved across species, with only minor differences in its sequence. PSMB1 is a Type I transmembrane protein that is expressed in the cytoplasm and cytoskeleton. It consists of a single polypeptide chain that is encoded by the gene Psmb1.

PSMB1 functions as a structural protein that forms the base of the nested beta-helices in the proteasome complex. Its conserved amino acid sequence is important for its structural role in this process. The nested beta-helices in the proteasome complex form a framework that allows for the efficient recognition and cleavage of foreign peptides by the proteasome.

PSMB1 is involved in the regulation of protein degradation in the cell. It functions as a chaperone that helps to transport and present foreign peptides to the ribosome for protein synthesis. In addition, PSMB1 is involved in the regulation of protein homeostasis, which is the process of maintaining the concentration of protein in the cell.

Mutations in PSMB1 have been linked to a wide range of diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. For example, studies have shown that individuals with certain genetic mutations, such as those in the PSMB1 gene, are at increased risk for developing Alzheimer's disease.

PSMB1 as a Drug Target

PSMB1 has been identified as a potential drug target due to its involvement in the regulation of protein degradation and homeostasis. Researchers are currently studying the potential benefits and risks of targeting PSMB1. One of the main goals of these studies is to develop small molecules that can inhibit the activity of PSMB1 and prevent its accumulation in damaged cells.

In addition to its potential as a drug target, PSMB1 has also been identified as a potential biomarker for a variety of diseases. The levels of PSMB1 have been shown to be elevated in the brains of individuals with Alzheimer's disease, which suggests that it may be a useful biomarker for this disease.

Conclusion

PSMB1 is a conserved protein that plays a crucial role in the regulation of protein degradation in the cell. Its functions as a chaperone and structural protein are essential for the efficient recognition and cleavage of foreign peptides by the proteasome. PSMB1 has

Protein Name: Proteasome 20S Subunit Beta 1

Functions: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

The "PSMB1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PSMB1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets