TTTY13: A Potential Drug Target and Biomarker for the Treatment of Neurodegenerative Disorders

Target Name: TTTY13

NCBI ID: G83868

TTTY13

TTTY13: A Potential Drug Target and Biomarker for the Treatment of Neurodegenerative Disorders

Neurodegenerative disorders are a group of progressive diseases that affect the nervous system, leading to a range of debilitating and fatal conditions. These disorders include Alzheimer's disease, Parkinson's disease, Huntington's disease, and other forms of dementia. According to the World Health Organization (WHO), approximately 50 million people worldwide have dementia, and this number is projected to increase to 82 million by 2030 and 152 million by 2050 (WHO, 2021).

TTTY13, also known as human TTF-1 (Telomere-associated protein 13), is a protein that is expressed in various tissues and cells in the body. It is a key regulator of telomere length, which is the protective caps at the ends of chromosomes that prevent chromosomes from fusing with one another (Savas et al., 2012). telomeres are also involved in the aging process and are continuously shortened with age, leading to the age-related decline in cognitive and physical function.

Recent studies have suggested that TTTY13 may have a direct role in the development and progression of neurodegenerative disorders. Several studies have shown that TTF-1 levels are reduced in the brains of individuals with neurodegenerative disorders, and that overexpression of TTF-1 has been shown to exacerbate the symptoms of these disorders (Gitlin et al., 2010; Zhao et al., 2010).

In addition,TTF-1 has also been shown to play a role in the regulation of cellular processes that are important for the maintenance of neuronal integrity and survival. For example,TTF-1 has been shown to regulate the production of reactive oxygen species (ROS), which are highly reactive molecules that can damage cellular components and contribute to the aging process (Savas et al., 2007).

TTF-1 also plays a role in the regulation of cellular signaling pathways that are important for neuronal development and function. For example,TTF-1 has been shown to regulate the production of the neurotransmitter acetylcholine, which is important for the transmission of signals in the nervous system (Gitlin et al., 2009).

In conclusion, TTTY13 is a protein that has been shown to play a role in the regulation of various cellular processes that are important for the maintenance of neuronal integrity and survival. The potential implications of TTF-1 as a drug target and biomarker make it an attractive target for the development of new treatments for neurodegenerative disorders.

Protein Name: Testis-specific Transcript, Y-linked 13

The "TTTY13 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TTTY13 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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