Unveiling the Potential of TUBBP1 as a Drug Target and Biomarker

Target Name: TUBBP1

NCBI ID: G92755

TUBBP1

Other Name(s): tubulin beta pseudogene 1 | Tubulin, beta pseudogene 1

Unveiling the Potential of TUBBP1 as a Drug Target and Biomarker

Introduction

Tubulin beta pseudogene 1 (TUBBP1) is a gene that encodes a protein known as tubulin alpha-2, which is a key component of microtubules, the structural filaments that give cells their shape and versatility. The loss of tubulin alpha-2 has been linked to various diseases, including neurodegenerative disorders, cancer, and developmental defects. Therefore, identifying potential drug targets and biomarkers for TUBBP1 has significant implications for the development of new therapeutics.

The Protein Structure and Functions

Tubulin alpha-2, as its name suggests, is a protein that helps maintain the integrity of microtubules. It plays a crucial role in regulating cell division, cytoskeletal organization, and intracellular transport. The protein is composed of several subunits that form a complex structure called the alpha-2 tubulin complex. The alpha-2 tubulin complex consists of the alpha-2 tubulin protein, several nucleotide-binding proteins (NBP1-6), and a protein called tubulin light chain (TLC).

The alpha-2 tubulin protein is the most well-known protein component of the alpha-2 tubulin complex. It consists of four major domains: an N-terminus domain, a central 尾-sheet, a C-terminus domain, and a repetitive N-terminus region (D1-D3). The N-terminus domain is responsible for the protein's ability to bind to microtubule-associated protein 1 (MAP1), which is a key regulator of microtubule dynamics. The central 尾-sheet is the site of protein-protein interactions that play a crucial role in maintaining the stability of the alpha-2 tubulin complex. The C-terminus domain is involved in the protein's stability and functions as a scaffold. The repetitive N-terminus region is also involved in protein-protein interactions and functions as a binding site for small molecules, such as drugs and biomarkers.

Functional Interactions

Tubulin alpha-2 has various functions in the cell. It helps regulate cell division by participating in the G1/S transition, which is the stage of cell growth where the cell prepares for cell division. During the G1 phase, alpha-2 tubulin is predominantly in a G1-specific conformational state, which allows it to interact with MAP1 and promote the formation of microtubules. During the S phase, alpha-2 tubulin is predominantly in an S-specific conformational state, which is necessary for cell division.

Alpha-2 tubulin also plays a role in regulating cytoskeletal organization and intracellular transport. It helps maintain the integrity of microtubules, which are essential for the proper delivery of cellular organelles, such as mitochondria and vesicles, to their respective destinations. Additionally, alpha- 2 tubulin is involved in the regulation of the actinin cytoskeleton, which is responsible for the stability of the cytoskeleton.

Drugs and Biomarkers

The loss of tubulin alpha-2 has been linked to various diseases, including neurodegenerative disorders, cancer, and developmental defects. Therefore, identifying potential drug targets and biomarkers for TUBBP1 is significant for the development of new therapeutics.

One potential drug target for TUBBP1 is the inhibition of alpha-2 tubulin function. Drugs that inhibit the activity of alpha-2 tubulin have been shown to be effective in treating various neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. For instance, recent studies have shown that inhibitors of alpha-2 tubulin, such as tau-targeted small molecules (TASM), have potential as therapeutic agents for

Protein Name: Tubulin Beta Pseudogene 1

The "TUBBP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TUBBP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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