Unveiling the Potential Drug Target TUBA1C: MGC14580 and its Potential Implications in Cancer Treatment

Target Name: TUBA1C

NCBI ID: G84790

TUBA1C

Unveiling the Potential Drug Target TUBA1C: MGC14580 and its Potential Implications in Cancer Treatment

Abstract:
TUBA1C (Tubulin-associated protein 1C), a protein encoded by the gene IPF2, has been identified as a potential drug target and biomarker for various diseases, including cancer. This protein plays a critical role in the structure and function of microtubules, which are essential for cell division and survival. In this article, we will discuss the current understanding of TUBA1C, its potential drug targets, and its implications in cancer treatment.

Introduction:
Cancer is one of the leading causes of morbidity and mortality worldwide, affecting millions of individuals worldwide. The development of new treatments for cancer has become a major focus of research in recent years. One of the promising strategies in cancer treatment is the targeting of protein targets that are involved in cell division, survival, and angiogenesis. TUBA1C, a protein that has been identified as a potential drug target and biomarker for cancer, is an attractive target due to its critical role in the structure and function of microtubules.

Current Understanding of TUBA1C:
TUBA1C is a 21-kDa protein that is encoded by the gene IPF2. It is highly conserved across various species, including humans, and has been shown to play a critical role in the structure and function of microtubules. Microtubules are essential for cell division, intracellular transport, and cytoskeletal organization. TUBA1C is involved in the formation and stability of microtubules and has been shown to play a critical role in the regulation of cell division and cytoskeletal organization.

In addition to its role in cell division and cytoskeletal organization, TUBA1C is also involved in the regulation of angiogenesis, a process that is critical for the formation of new blood vessels in the body. This is important for various diseases, including cancer, where the growth of new blood vessels can contribute to tumor progression and the development of invasive and metastatic phenotypes.

Potential Drug Targets:
TUBA1C has been identified as a potential drug target due to its critical role in cell division, survival, and angiogenesis. Several studies have shown that TUBA1C can be targeted by small molecules, including inhibitors of the tubulin-associated protein 1C (T-SPP) domain, which is a key component of TUBA1C. These inhibitors have been shown to have a range of therapeutic effects, including the inhibition of cancer cell growth, the inhibition of angiogenesis, and the disruption of microtubule stability.

In addition to its potential as a drug target, TUBA1C has also been identified as a potential biomarker for cancer. The loss of TUBA1C has been observed in various types of cancer, including breast, ovarian, and colorectal cancers. This suggests that TUBA1C may be a useful biomarker for the diagnosis and prognosis of cancer.

Implications in Cancer Treatment:
The identification of TUBA1C as a potential drug target and biomarker for cancer makes it an attractive target for cancer treatment. Small molecules inhibitors of the T-SPP domain have been shown to have a range of therapeutic effects, including the inhibition of cancer cell growth, the inhibition of angiogenesis, and the disruption of microtubule stability. These inhibitors can be delivered to cancer cells in a targeted and efficient manner, leading to a reduction in the growth and spread of cancer.

In addition to its potential as a drug target, TUBA1C has also been identified as a potential biomarker for cancer. The loss of TUBA1C has

Protein Name: Tubulin Alpha 1c

Functions: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

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•   expression level;
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•   related combination drugs;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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