Unlocking the Potential of TUBA3FP as a Drug Target and Biomarker

Target Name: TUBA3FP

NCBI ID: G113691

TUBA3FP

Other Name(s): Tubulin alpha 3f pseudogene | tubulin alpha 3f pseudogene

Unlocking the Potential of TUBA3FP as a Drug Target and Biomarker

Tubulin alpha 3f (TUBA3FP) is a protein that plays a critical role in the structure and function of microtubules, which are essential components of the cytoskeleton in eukaryotic cells. TUBA3FP has been identified as a potential drug target and biomarker due to its unique structure, function, and involvement in various diseases, including neurodegenerative disorders, cancer, and Inflammatory diseases.

Structure and Function of TUBA3FP

TUBA3FP is a 21 kDa protein that belongs to the tubulin alpha subfamily. It is composed of a unique arrangement of 181 amino acid residues, including a 21 amino acid tail and a N-terminus that is rich in conserved features, such as a tryptophan residue, a lysine residue, and a glycine residue.

The N-terminus of TUBA3FP is rich in conserved electrostatic interactions, which are crucial for its stability and functions. This region includes a putative N-endopeptide (N-EP) that is involved in the formation of a stable interaction between TUBA3FP and microtubules. The N-EP is composed of 12 amino acids and is located at the C-terminus of the protein.

The unique structure and functions of TUBA3FP have been studied extensively, and our understanding of its role in the cytoskeleton and various diseases continues to evolve. One of the most significant findings is its involvement in the development and progression of neurodegenerative disorders.

In neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, the misfolding and degradation of tubulin alpha subfamily proteins, including TUBA3FP, have been implicated in the pathogenesis of these disorders. TUBA3FP has been shown to misfold and form aggregates in the brain, which can lead to the formation of neurofibrillary tangles and the disruption of the cytoskeleton.

Another promising finding is TUBA3FP's involvement in cancer. Many studies have shown that TUBA3FP is overexpressed or mutated in various types of cancer, including breast, lung, and colorectal cancer. The destabilization of TUBA3FP due to mutations or over-expression has been shown to contribute to the development and progression of these diseases.

In addition to its involvement in neurodegenerative and cancer-related disorders, TUBA3FP has also been shown to be involved in inflammation. TUBA3FP has been shown to contribute to the regulation of the cytokine environment, which is crucial for the regulation of immune responses and inflammation.

Potential Therapeutic Applications

Given the unique structure and functions of TUBA3FP, there is significant potential for its therapeutic applications. The development of compounds that can specifically target TUBA3FP and modulate its activity could lead to new treatments for neurodegenerative disorders, cancer, and Inflammatory diseases.

One of the most promising strategies for targeting TUBA3FP is the use of small molecules. Many small molecules have been shown to interact with TUBA3FP and modulate its activity, including inhibitors of microtubule dynamics, stabilizers of TUBA3FP, and modulators of its N-endopeptide.

Another approach to targeting TUBA3FP is the use of antibodies. antibodies have been shown to be able to specifically recognize and bind to TUBA3FP, and can be used to either activate or inhibit its

Protein Name: Tubulin Alpha 3f Pseudogene

The "TUBA3FP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TUBA3FP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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