tubulin alpha pseudogene 7 (TUBAP7): A Promising Drug Target and Biomarker

Target Name: TUBAP7

NCBI ID: G644436

TUBAP7

Other Name(s): tubulin alpha pseudogene 7 | LOC644436 | Tubulin alpha 4a pseudogene

tubulin alpha pseudogene 7 (TUBAP7): A Promising Drug Target and Biomarker

Tubulin alpha pseudogene 7 (TUBAP7) is a gene that encodes a protein known as tubulin alpha-2 (T伪2), which is a key component of microtubules, the structural framework that organizes and transports proteins within cells. T伪2 plays a crucial role in cell division, intracellular transport, and other cellular processes. The TUBAP7 gene has been identified as a potential drug target and biomarker due to its involvement in various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases.

Diseases and Their Connection to TUBAP7

Tubulin alpha-2 (T伪2) is a highly conserved protein that is found in various cell types, including neurons, muscle cells, and red blood cells. It plays a vital role in the formation and maintenance of microtubules, which are essential for the proper functioning of cells. Alterations in T伪2 levels or its dysfunction can lead to various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases.

Neurodegenerative Disorders

Neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by the progressive loss of brain cells and the damage to neural circuits that support normal brain function. These disorders are associated with the accumulation of neurofibrillary tangles and the presence of abnormally shaped cells, including T伪2-positive neurons.

Tubulin alpha-2 (T伪2) is involved in the formation and maintenance of microtubules, which are thought to play a crucial role in the survival of neurons. Studies have shown that T伪2 levels are reduced in the brains of individuals with neurodegenerative disorders, and that restoring T伪2 function to these cells may have therapeutic benefits. Therefore, TUBAP7 has potential as a drug target for neurodegenerative disorders.

Cancer

Tubulin alpha-2 (T伪2) is also involved in the regulation of cell division and the maintenance of normal cell growth. Many studies have shown that T伪2 levels are altered in various types of cancer, including breast, lung, and ovarian cancer. In addition, T伪2 has been implicated in the development and progression of certain types of cancer.

For instance, studies have shown that T伪2 levels are reduced in breast cancer cells, and that restoring T伪2 function to these cells may have therapeutic benefits. Similarly, T伪2 has been shown to be involved in the development and progression of certain types of lung cancer.

Autoimmune Diseases

Autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis, are characterized by the immune system attacking the body's own tissues and organs. These diseases are associated with the production of antibodies that target self-antigens, including proteins like T伪2.

Tubulin alpha-2 (T伪2) is involved in the formation and maintenance of microtubules, which are thought to play a role in the immune response. Therefore, T伪2 has potential as a drug target for autoimmune diseases.

Potential Therapeutic Benefits

Tubulin alpha-2 (T伪2) has been identified as a potential drug target due to its involvement in various diseases. The development of compounds that can specifically target T伪2 and modulate its function may have therapeutic benefits.

One approach to targeting T伪2 is through small molecule inhibitors. These compounds can be designed to specifically bind to T伪2 and prevent its function in microtubule formation and maintenance. By inhibiting T伪2 function, these compounds may have therapeutic benefits for neurodegenerative disorders, cancer, and autoimmune diseases.

Another approach to targeting T伪2 is through monoclonal antibodies (MCABs). These antibodies are designed to selectively bind to a specific protein and can be used to treat diseases associated with the dysfunction of T伪2.

Conclusion

Tubulin alpha-2 (T伪2) is a protein that is involved in the formation and maintenance of microtubules and has been implicated in various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. The development of compounds that can specifically target T伪2 and modulate its function may have therapeutic benefits. Further research is needed to fully understand the role of T伪2 in these diseases and to develop safe and effective treatments.

Protein Name: Tubulin Alpha Pseudogene 7

The "TUBAP7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TUBAP7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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