ANO2: A Transmembrane Protein Involved in Cell Signaling and Tissue Maintenance
ANO2: A Transmembrane Protein Involved in Cell Signaling and Tissue Maintenance
ANO2, or transmembrane protein 16B, is a protein that is expressed in various tissues throughout the body. It plays a critical role in the regulation of cell signaling pathways, and is a key player in the development and maintenance of tissues such as the brain, heart, and kidneys.
ANO2 is a four-domain transmembrane protein that consists of an N-terminal transmembrane domain, a protein transmembrane domain, a C-terminal transmembrane domain, and an V-terminal cytoplasmic domain. The N-terminal transmembrane domain is responsible for the formation of the protein's transmembrane region, while the C-terminal and V-terminal domains are involved in the regulation of the protein's stability and localization to different cell types.
One of the unique features of ANO2 is its eight membrane-spanning domains. These domains are arranged in a repeating pattern of two parallel beta-helices, which form the basis of the protein's transmembrane structure. The eight membrane-spanning domains give ANO2 its unique 8-fold repeat structure, and are involved in the regulation of the protein's stability and localization to different cell types.
ANO2 is involved in a wide range of physiological processes in the body, including the regulation of cell signaling pathways, the development and maintenance of tissues, and the regulation of ion and water transport. It is well established that ANO2 plays a critical role in the development and maintenance of the brain, heart, and kidneys, and is involved in the regulation of a wide range of physiological processes that are critical for human health and survival.
Despite the importance of ANO2 in human health, the development of effective therapies for ANO2-related diseases remains a major challenge. Currently, there are limited treatment options available for diseases that are characterized by the dysfunction or dysfunctional regulation of ANO2.
In conclusion, ANO2 is a transmembrane protein that is involved in a wide range of physiological processes in the body. Its eight membrane-spanning domains give it a unique structure that is involved in the regulation of cell signaling pathways, and its critical role in the development and maintenance of tissues makes it an attractive target for future therapies. Further research is needed to develop effective treatments for ANO2-related diseases.
Protein Name: Anoctamin 2
Functions: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina
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More Common Targets
ANO3 | ANO4 | ANO5 | ANO6 | ANO7 | ANO7L1 | ANO8 | ANO9 | Anoctamin | ANOS1 | ANOS2P | ANP32A | ANP32A-IT1 | ANP32AP1 | ANP32B | ANP32C | ANP32D | ANP32E | ANPEP | ANTKMT | ANTXR1 | ANTXR2 | ANTXRL | ANTXRLP1 | ANXA1 | ANXA10 | ANXA11 | ANXA13 | ANXA2 | ANXA2P1 | ANXA2P2 | ANXA2P3 | ANXA2R | ANXA2R-AS1 | ANXA2R-OT1 | ANXA3 | ANXA4 | ANXA5 | ANXA6 | ANXA7 | ANXA8 | ANXA8L1 | ANXA8L2 | ANXA9 | AOAH | AOC1 | AOC2 | AOC3 | AOC4P | AOPEP | AOX1 | AOX2P | AP-1 Transcription Factor Complex | AP1AR | AP1B1 | AP1B1P1 | AP1G1 | AP1G2 | AP1M1 | AP1M2 | AP1S1 | AP1S2 | AP1S3 | AP2A1 | AP2A2 | AP2B1 | AP2M1 | AP2S1 | AP3B1 | AP3B2 | AP3D1 | AP3M1 | AP3M2 | AP3S1 | AP3S2 | AP4B1 | AP4B1-AS1 | AP4E1 | AP4M1 | AP4S1 | AP5B1 | AP5M1 | AP5S1 | AP5Z1 | APAF1 | APBA1 | APBA2 | APBA3 | APBB1 | APBB1IP | APBB2 | APBB3 | APC | APC2 | APCDD1 | APCDD1L | APCDD1L-DT | APCS | APEH | APELA
