Target Name: ANKS4B
NCBI ID: G257629
Review Report on ANKS4B Target / Biomarker Content of Review Report on ANKS4B Target / Biomarker
ANKS4B
Other Name(s): Ankyrin repeat and SAM domain-containing protein 4B | harmonin-interacting ankyrin-repeat containing protein | Harmonin-interacting ankyrin-repeat containing protein | HARP | Ankyrin repeat and sterile alpha motif domain containing 4B | Harp | ankyrin repeat and sterile alpha motif domain containing 4B | Harmonin-interacting ankyrin repeat-containing protein | ANS4B_HUMAN

ANKS4B: A Potential Drug Target and Biomarker

Ankyrin repeat and SAM domain-containing protein 4B (ANKS4B) is a protein that has been identified as a potential drug target and biomarker. ANKS4B is a 21-kDa protein that is expressed in various tissues and cells, including brain, heart, and skeletal muscles. It is characterized by an N-terminal SAM domain, a unique feature that is found in only a small number of proteins. The SAM domain is known for its ability to form a complex with other proteins, including drug targets.

Drug Target Potential

The potential drug target for ANKS4B is its ability to interact with other proteins and to regulate their activity. Many drugs work by modulating the activity of specific proteins, leading to the development of diseases such as cancer, neurodegenerative diseases, and cardiovascular diseases. ANKS4B is thought to be a drug target because of its involvement in various cellular processes that are important for human health and disease.

One of the key functions of ANKS4B is its role in intracellular signaling. It is involved in the regulation of protein kinase (PK) activity, which is a critical step in many cellular processes. ANKS4B has been shown to interact with several different PKs, including casein kinase (CK) 2,3, and 11. This interaction suggests that ANKS4B may be a drug target forPK inhibitors.

Another potential drug target for ANKS4B is its role in cell survival and proliferation. ANKS4B has been shown to be involved in the regulation of cell survival and proliferation, which is important for the development and progression of many diseases. The ANKS4B gene has been shown to be involved in the regulation of cell cycle progression, and it has been suggested that it may be a drug target for inhibitors of the G1 cell cycle checkpoint.

Biomarker Potential

In addition to its potential as a drug target, ANKS4B may also be a useful biomarker for some diseases. The ANKS4B gene has been shown to be involved in the regulation of various cellular processes, including protein synthesis, DNA replication, and cell survival. This suggests that ANKS4B may be a useful biomarker for diseases that are characterized by the disruption of these processes, such as cancer, neurodegenerative diseases, and cardiovascular diseases.

One of the key advantages of ANKS4B as a biomarker is its stability. Unlike many other proteins, ANKS4B is expressed in a stable form in various tissues and cells, which makes it a potential candidate for use as a biomarker. This stability may also make it more reliable as a biomarker compared to proteins that are expressed in variable forms, such as many proteins that are expressed in brain and heart cells.

Conclusion

In conclusion, ANKS4B is a protein that has been identified as a potential drug target and biomarker. Its unique SAM domain and its involvement in intracellular signaling and cell survival and proliferation make it a promising target for the development of new drugs. Further research is needed to fully understand the potential of ANKS4B as a drug target and biomarker.

Protein Name: Ankyrin Repeat And Sterile Alpha Motif Domain Containing 4B

Functions: As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity)

The "ANKS4B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ANKS4B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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