ANP32E: Key Regulator of DNA Replication and Stress Response (G81611)

Target Name: ANP32E

NCBI ID: G81611

ANP32E

Other Name(s): Acidic leucine-rich nuclear phosphoprotein 32 family member E (isoform 5) | Acidic nuclear phosphoprotein 32 family member E, transcript variant 5 | ANP32E variant 2 | LANP-L | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | LANPL | Acidic leucine-rich nuclear phosphoprotein 32 family member E (isoform 2) | ANP32E variant 1 | Acidic nuclear phosphoprotein 32 family member E, transcript variant 1 | Acidic leucine-rich nuclear phosphoprotein 32 family member E (isoform 1) | Acidic leucine-rich nuclear phosphoprotein 32 family member E | ANP32E variant 5 | LANP-like protein | MGC5350 | acidic nuclear phosphoprotein 32 family member E | Leucine-rich acidic nuclear protein like | AN32E_HUMAN | Acidic nuclear phosphoprotein 32 family member E, transcript variant 2 | leucine-rich acidic nuclear protein like

ANP32E: Key Regulator of DNA Replication and Stress Response

ANP32E, also known as Acidic leucine-rich nuclear phosphoprotein 32 family member E (isoform 5), is a protein that is expressed in various tissues throughout the body. It is a key regulator of DNA replication and repair, and is involved in the repair of DNA damage caused by various forms of stress, such as UV radiation, radiation, and chemical agents.

ANP32E is a member of the Acidic leucine-rich nuclear phosphoprotein (ALRP) family, which is characterized by the presence of a conserved N-terminal region that contains a leucine-rich repeat and a catalytic alpha-helicase domain. This family also includes several other proteins, including ALRP1, ALRP2, and ALRP3, which are involved in various cellular processes, including DNA replication, gene expression, and stress response.

One of the unique features of ANP32E is its acidic pH, which is characteristic of proteins that are involved in acid-base regulation. This property allows ANP32E to interact with various molecules and participate in a wide range of cellular processes, including DNA replication, repair , and stress response.

ANP32E is also involved in the regulation of DNA replication, which is a critical process that is essential for the growth and development of all living organisms. DNA replication involves the synthesis of a new double helix of DNA from two complementary strands, which is then replicated by the cell to ensure the continuation of genetic information.

ANP32E is a key regulator of DNA replication, as it plays a role in the regulation of the priming of the DNA replication complex. This complex consists of several proteins, including the DNA-binding protein MBD1, which is responsible for binding to the double helix , and the romance protein TRF2, which is involved in the recruitment of the necessary enzymes for the initiation of the replication process.

ANP32E is also involved in the regulation of DNA repair, which is a critical process that is essential for the maintenance of genetic integrity in the cell. DNA repair involves the repair of DNA damage caused by various forms of stress, such as UV radiation, radiation , and chemical agents.

ANP32E is a key regulator of DNA repair, as it plays a role in the regulation of the DNA repair machinery. This machinery consists of several proteins, including the DNA-binding protein XRCC1, which is responsible for repairing DNA damage, and the error- correcting protein APC/N-terminal domain protein (ANRP), which is involved in the detection and correction of DNA repair errors.

ANP32E is also involved in the regulation of stress response, which is a critical process that is essential for the survival of all living organisms. Stress response involves the regulation of various cellular processes, including the expression of genes involved in stress response, such as those involved in the production of reactive oxygen species (ROS), which can cause damage to cellular components and contribute to cellular stress.

ANP32E is a key regulator of stress response, as it plays a role in the regulation of the stress response pathway. This pathway involves the regulation of various cellular processes, including the production of ROS, the expression of genes involved in stress response, and the regulation of cellular stress responses.

In conclusion, ANP32E is a protein that is involved in a wide range of cellular processes, including DNA replication, repair, and stress response. Its acidic pH and ability to interact with various molecules make it a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of ANP32E in these processes and to develop new treatments for

Protein Name: Acidic Nuclear Phosphoprotein 32 Family Member E

Functions: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis

The "ANP32E Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ANP32E comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets