ANP32D: Regulation of Cell Cycle and Disease (G23519)

Target Name: ANP32D

NCBI ID: G23519

ANP32D

ANP32D: Regulation of Cell Cycle and Disease

ANP32D, also known as Acidic leucine-rich nuclear phosphoprotein 32 family member D, is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of the cell cycle, and is involved in the progression of cells through the different stages of cell division. ANP32D is also known as KCP2, and is a member of the KCP2 family of proteins.

The KCP2 family plays a vital role in the regulation of cell division and cell cycle progression. The KCP2 family consists of six different proteins, including ANP32D, KCP2A, KCP2B, KCP2C, KCP2D, and KCP2E. These proteins share a common structural domain, known as the KCP2 domain, which is responsible for their unique functions.

ANP32D is a 21 kDa protein that is expressed in various tissues and cells, including the brain, pancreas, and heart. It is involved in the regulation of the cell cycle, and is specifically targeted to the centrosome, which is the structural protein that forms the center of each cell. ANP32D is also involved in the metaphase of cell division, where the chromosomes are replicated and the replicated chromosomes move to the opposite ends of the cell.

One of the key functions of ANP32D is its role in the regulation of centriosomal spindle formation. During the metaphase phase of mitosis, centriolar spindle formation is necessary to ensure that chromosomes properly separate and move to the extreme ends of the cell. ANP32D is one of the key players in the formation of the centriole spindle. By binding to tubulin, ANP32D can regulate the assembly and deassembly of tubulin, thereby ensuring that the spindle forms the correct size and shape.

In addition, ANP32D is also closely related to the progression of mitosis. During late stages of mitosis, ANP32D binds to histone H3, a regulator of histone gene expression. Therefore, ANP32D activity and expression levels can be used to monitor mitotic progression.

In addition, ANP32D is also closely related to the occurrence and development of many diseases. For example, abnormal expression of ANP32D has been found to be associated with the progression and enhanced invasiveness of various cancers, such as breast, lung, and prostate cancer. In addition, ANP32D has been associated with neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, and liver diseases, such as cirrhosis.

Therefore, ANP32D is a promising drug target or biomarker. Studying the functional and pathological characteristics of ANP32D can reveal its role in cell cycle and disease, and provide an important theoretical basis for the development of new therapeutic methods and diagnostic tools.

Protein Name: Acidic Nuclear Phosphoprotein 32 Family Member D

The "ANP32D Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ANP32D comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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