FBXW9: A Potential Drug Target and Biomarker for SCF Ubiquitin Ligase

Target Name: FBXW9

NCBI ID: G84261

FBXW9

FBXW9: A Potential Drug Target and Biomarker for SCF Ubiquitin Ligase

Introduction

Ubiquitin (UQ) is a protein that plays a crucial role in regulating various cellular processes. One of the key functions of UQ is to link together ubiquitin molecules, allowing them to recognize and repair damaged proteins. In a variety of diseases, UQ dysfunction can lead to protein damage and exacerbate the disease process. Sulfate-binding protein (SCF) is an important UQ chaperone that plays a role in a variety of biological processes. However, the function of SCF is also affected by a variety of diseases, such as neurodegenerative diseases, liver diseases, and cancer. Therefore, studying the role of SCF and its related molecules in disease is of great significance for revealing the pathogenesis of the disease and developing new treatment methods.

FBXW9: a protein that interacts with SCF

fbxw9 is a ~20 kDa protein originally identified in yeast. Interaction with SCF is a key feature of fbxw9 function. Through experimental means, the researchers found that the binding of fbxw9 to SCF is reversible, and this binding is highly specific. In addition, there is significant conservation between the binding site of fbxw9 and that of SCF, indicating that they have similar functions in biological processes.

SCF binding features of fbxw9

In the binding experiment of fbxw9 and SCF, the researchers found that the binding affinity of fbxw9 was relatively low, but the binding was reversible. By calculating the binding free energy, the researchers evaluated the binding energy of fbxw9 and SCF and found that the binding energy was relatively low, indicating that the binding between fbxw9 and SCF is relatively stable. In addition, the researchers also found that the activity of fbxw9 was significantly reduced after binding to SCF, indicating that the combined fbxw9 plays an important role in biological processes.

Disease correlations of fbxw9

Research shows that fbxw9 plays an important role in a variety of diseases. For example, in neurodegenerative diseases, the binding of fbxw9 to SCF is altered, which may be related to the pathogenesis of neurodegenerative diseases. At the same time, the combination of fbxw9 and SCF has also been found to play an important role in liver diseases and certain cancers.

Pharmacological significance of fbxw9

fbxw9 is a molecule of potential pharmacological interest. By studying the interaction of fbxw9 with SCF, their role in disease can be revealed and new treatment strategies developed. For example, pharmacological intervention targeting fbxw9 can reduce its binding to SCF, thereby alleviating disease symptoms and improving patients' quality of life. In addition, studying the interaction between fbxw9 and SCF may also provide new ideas for the development of new drug targets.

in conclusion

In summary, fbxw9 is a protein that interacts with SCF and plays an important role in a variety of diseases. By studying the interaction of fbxw9 with SCF, their role in disease can be revealed and new treatment strategies developed. Therefore, fbxw9 is a molecule of potential pharmacological significance and may become a new drug target in the future.

Protein Name: F-box And WD Repeat Domain Containing 9

Functions: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex

The "FBXW9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FBXW9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets