A Potential Drug Target: FEZF1-AS1 (LOC154860) (G154860)
A Potential Drug Target: FEZF1-AS1 (LOC154860)
Fezf1-as1 (LOC154860), a protein encoded in the Fezf1 gene, is a non-coding RNA molecule that plays a crucial role in the development and progression of various diseases, including cancer. Its unique structure, functions, and subcellular localization make it an attractive drug target for researchers to explore. This article will provide an overview ofFEZF1-AS1, its functions, potential drug targets, and its potential as a biomarker.
FEZF1-AS1: Structure and Functions
FEZF1-AS1 is a 21-kDa protein that consists of an N-terminal transmembrane domain, a coiled-coil domain, and a C-terminal T-loop region. It has a characteristic hourglass shape and is composed of multiple distinct domains, including an N-terminal transmembrane domain, a coiled-coil domain, and a T-loop region.
The N-terminal transmembrane domain is responsible for the formation of a complex with various transcription factors, which allows it to interact with the host cell's DNA. This interaction is crucial for the protein's ability to regulate gene expression and contribute to the development of various diseases.
The coiled-coil domain is responsible for the protein's unique structure and stability. This region consists of multiple regions of coiled-coil, which can interact with other proteins and molecules, including transcription factors, to form a complex structure. This interaction between the protein and its ligands allows for the regulation of gene expression and the development of various diseases.
The C-terminal T-loop region is responsible for the protein's stability and interaction with various cellular signaling pathways. This region consists of a unique farnesylated cysteine residue, which is known to be involved in the regulation of protein stability and interacts with various signaling pathways, including the PI3K/AKT signaling pathway.
FEZF1-AS1's functions are wide-ranging and include the regulation of gene expression, cell signaling, and the development of various diseases. Its unique structure and subcellular localization make it an attractive drug target for researchers to explore.
Potential Drug Targets
FEZF1-AS1 has several potential drug targets due to its unique structure and functions. Some of the most promising targets include:
1. Gli: Gli is a gene that encodes the protein Gli, which is known to be involved in the regulation of cell signaling pathways, including the PI3K/AKT signaling pathway. Gli has been linked to the development of various diseases, including cancer. By targeting Gli, researchers may be able to prevent the development of these diseases by inhibiting its activity.
2. NF-kappa-B: NF-kappa-B is a gene that encodes the protein NF-kappa-B, which is involved in the regulation of inflammation and pain signaling pathways. NF-kappa-B has been linked to the development of various diseases, including cancer. By targeting NF-kappa-B, researchers may be able to prevent the development of these diseases by inhibiting its activity.
3. TNF-伪: TNF-伪 is a gene that encodes the protein TNF-伪, which is involved in the regulation of inflammation and immune responses. TNF-伪 has been linked to the development of various diseases, including cancer. By targeting TNF-伪, researchers may be able to prevent the development of these diseases by inhibiting its activity.
Potential as a Biomarker
FEZF1-AS1 has the potential to serve as a biomarker for various diseases. Its unique structure and functions make it an attractive target for researchers to explore. By using techniques such as qRT-PCR, RNA sequencing, and western blotting, researchers may be able to detect and measure the expression of FEZF1-AS1 in various tissues and cells, including cancer cells
Protein Name: FEZF1 Antisense RNA 1
The "FEZF1-AS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FEZF1-AS1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
FEZF2 | FFAR1 | FFAR2 | FFAR3 | FFAR4 | FGA | FGB | FGD1 | FGD2 | FGD3 | FGD4 | FGD5 | FGD5-AS1 | FGD5P1 | FGD6 | FGF1 | FGF10 | FGF10-AS1 | FGF11 | FGF12 | FGF12-AS2 | FGF13 | FGF13-AS1 | FGF14 | FGF14-AS1 | FGF14-AS2 | FGF14-IT1 | FGF16 | FGF17 | FGF18 | FGF19 | FGF2 | FGF20 | FGF21 | FGF22 | FGF23 | FGF3 | FGF4 | FGF5 | FGF6 | FGF7 | FGF7P3 | FGF7P5 | FGF7P6 | FGF8 | FGF9 | FGFBP1 | FGFBP2 | FGFBP3 | FGFR1 | FGFR1OP2 | FGFR2 | FGFR3 | FGFR3P1 | FGFR4 | FGFRL1 | FGG | FGGY | FGL1 | FGL2 | FGR | FH | FHAD1 | FHDC1 | FHF Complex | FHIP1A | FHIP1B | FHIP2A | FHIP2B | FHIT | FHL1 | FHL2 | FHL3 | FHL5 | FHOD1 | FHOD3 | FIBCD1 | FIBIN | FIBP | Fibrinogen | Fibroblast growth factor (FGF) | Fibroblast Growth Factor Receptor (FGFR) | Fibronectin Type III Domain | FICD | FIG4 | FIGLA | FIGN | FIGNL1 | FIGNL2 | FILIP1 | FILIP1L | FILNC1 | FIP1L1 | FIRRE | FIS1 | FITM1 | FITM2 | Five friends of methylated CHTOP complex | FIZ1 | FJX1
