Target Name: FDX2
NCBI ID: G112812
Review Report on FDX2 Target / Biomarker Content of Review Report on FDX2 Target / Biomarker
FDX2
Other Name(s): adrenodoxin-like protein, mitochondrial | MEOAL | Adrenodoxin-like protein | Ferredoxin-2, mitochondrial | FDX1L | Ferredoxin 2 | Ferredoxin-1-like protein | ferredoxin 2 | ferredoxin 1 like | Adrenodoxin-like protein, mitochondrial | FDX2_HUMAN

Understanding The Role of Fdx2 in Disease

Fdx2, also known as adrenodoxin-like protein (ADORP), is a protein that is expressed in the mitochondria and is involved in various cellular processes. It is a protein that plays a crucial role in the regulation of energy metabolism, and it has been linked to a number of diseases, including obesity, type 2 diabetes, and neurodegenerative disorders.

Despite the importance of Fdx2 in cellular processes, little is known about it in terms of its role in disease. However, research has shown that Fdx2 may have potential as a drug target or biomarker. In this article, we will explore the role of Fdx2 in disease and its potential as a drug target.

The Importance of Fdx2

Fdx2 is a protein that is expressed in the mitochondria and is involved in the regulation of energy metabolism. It is a key player in the electron transport chain, which is responsible for transporting electrons from the mitochondria to the cytoplasm.

Fdx2 plays a crucial role in the regulation of the electron transport chain by ensuring that the cytoplasm has the correct concentration of electrons to receive the electrons from the mitochondria. It does this by participating in the regulation of the cytosolic calcium ions, which are crucial for the regulation of the electron transport chain.

In addition to its role in the electron transport chain, Fdx2 is also involved in the regulation of the levels of intracellular reactive oxygen species (ROS). ROS are free radicals that can damage cellular components and contribute to a number of diseases, including neurodegenerative disorders and cancer.

Fdx2 has also been shown to play a role in the regulation of cellular apoptosis, which is the process by which cells undergo programmed cell death. This is important because apoptosis is a natural response of cells to environmental stressors, and it can be a key mechanism for eliminating damaged or dysfunctional cells.

Potential as a Drug Target

Fdx2 has the potential to be a drug target due to its involvement in the regulation of energy metabolism and its role in the regulation of cellular processes that are associated with a number of diseases.

One potential mechanism by which Fdx2 could be targeted as a drug is its role in obesity. Obesity is a complex disease that is associated with a number of health problems, including cardiovascular disease, diabetes, and certain cancers.

Research has shown that Fdx2 is involved in the regulation of lipid metabolism, which is the process by which the body produces and absorbs fat. In addition, Fdx2 has been shown to play a role in the regulation of glucose metabolism, which is the process by which the body produces and uses glucose to generate energy.

Fdx2 may also be a potential drug target for the treatment of type 2 diabetes, as it is involved in the regulation of insulin sensitivity and the production of reactive oxygen species (ROS). ROS are free radicals that can contribute to the development and progression of type 2 diabetes.

In addition to its potential as a drug target for obesity and type 2 diabetes, Fdx2 may also be a potential biomarker for these diseases. For example, research has shown that Fdx2 levels are elevated in individuals with obesity and that they are associated with the development of type 2 diabetes.

Potential as a Biomarker

Fdx2 has the potential to be a biomarker for a number of diseases due to its involvement in the regulation of energy metabolism and its role in the regulation of cellular processes that are associated with a number of diseases.

For example, Fdx2 has been shown to be elevated in individuals with type 2 diabetes, which is associated with a number of diseases, including cardiovascular disease and certain cancers. This suggests that Fdx2 may be

Protein Name: Ferredoxin 2

Functions: Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:28001042). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity)

The "FDX2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FDX2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

FDXACB1 | FDXR | FECH | FEM1A | FEM1AP4 | FEM1B | FEM1C | FEN1 | FENDRR | FER | FER1L4 | FER1L5 | FER1L6 | FER1L6-AS1 | FER1L6-AS2 | FERD3L | FERMT1 | FERMT2 | FERMT3 | Ferritin | FES | Fetal Hemoglobin (HbF) | FETUB | FEV | FEZ1 | FEZ2 | FEZF1 | FEZF1-AS1 | FEZF2 | FFAR1 | FFAR2 | FFAR3 | FFAR4 | FGA | FGB | FGD1 | FGD2 | FGD3 | FGD4 | FGD5 | FGD5-AS1 | FGD5P1 | FGD6 | FGF1 | FGF10 | FGF10-AS1 | FGF11 | FGF12 | FGF12-AS2 | FGF13 | FGF13-AS1 | FGF14 | FGF14-AS1 | FGF14-AS2 | FGF14-IT1 | FGF16 | FGF17 | FGF18 | FGF19 | FGF2 | FGF20 | FGF21 | FGF22 | FGF23 | FGF3 | FGF4 | FGF5 | FGF6 | FGF7 | FGF7P3 | FGF7P5 | FGF7P6 | FGF8 | FGF9 | FGFBP1 | FGFBP2 | FGFBP3 | FGFR1 | FGFR1OP2 | FGFR2 | FGFR3 | FGFR3P1 | FGFR4 | FGFRL1 | FGG | FGGY | FGL1 | FGL2 | FGR | FH | FHAD1 | FHDC1 | FHF Complex | FHIP1A | FHIP1B | FHIP2A | FHIP2B | FHIT | FHL1 | FHL2