FERMT3: Protein Involved in Multiple Physiological Processes (G83706)
FERMT3: Protein Involved in Multiple Physiological Processes
Fermitin family member 3 (FERMT3) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the Fermitin family, which is known for its role in cell-cell adhesion and migration.
FERMT3 has been shown to play a role in several physiological processes in the body, including cell signaling, migration, and invasion. It is involved in the formation of tight junctions, which are specialized barriers that allow cells to communicate with each other and to maintain tissue structure.
In addition to its role in cell-cell adhesion, FERMT3 has also been shown to play a role in the regulation of pain perception. It is expressed in the endodermis, which is the outermost layer of the body, and has been shown to be involved in the development of pain fibers.
FERMT3 is also involved in the regulation of inflammation. It is expressed in the inflammatory response and has been shown to play a role in the recruitment of immune cells to the site of inflammation.
In addition to its role in cell signaling and inflammation, FERMT3 is also involved in the regulation of cell growth. It is expressed in the S phase of cell division and has been shown to play a role in the regulation of cell cycle progression.
FERMT3 has also been shown to play a role in the regulation of stem cell proliferation. It is expressed in stem cells and has been shown to play a role in the maintenance of stem cell stemness.
In addition to its role in stem cell proliferation, FERMT3 is also involved in the regulation of tissue repair. It is expressed in the wound healing process and has been shown to play a role in the regulation of cell proliferation and differentiation in response to tissue injury.
In conclusion, FERMT3 is a protein that is involved in a variety of physiological processes in the body. Its role in cell-cell adhesion, pain perception, inflammation, cell growth, stem cell proliferation, and tissue repair make it an attractive drug target for researchers. Further studies are needed to fully understand the role of FERMT3 in these processes and to develop effective treatments.
Protein Name: FERM Domain Containing Kindlin 3
Functions: Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity)
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• expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
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