ACSS1: A Protein Involved in Water Transport and Cell Survival

Target Name: ACSS1

NCBI ID: G84532

ACSS1

ACSS1: A Protein Involved in Water Transport and Cell Survival

ACSS1 (ACSS1 variant 1) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the aquaporin (APC) gene family, which encodes a family of water-channel proteins that play a crucial role in the regulation of water transport in various body systems.

ACSS1 is characterized by its ability to form a homo-dimeric complex with other APC proteins, such as AQP2 (aquaporin 2) and AQP8 (aquaporin 8). This interaction between ACSS1 and AQP2/AQP8 is important for the regulation of water transport in various body systems, including the brain.

The ACSS1 protein has been shown to play a role in the regulation of water transport in the brain, where it is expressed in the peri-synaptic water-channel protein, which is involved in the regulation of the flow of water into and out of nerves cells. Additionally, ACSS1 has been shown to be involved in the regulation of water transport in the heart, where it is expressed in the cardiac intercellular water-channel protein, which is involved in the regulation of the flow of water into and out of heart cells.

ACSS1 has also been shown to play a role in the regulation of water transport in the kidneys, where it is expressed in the kidney collecting tubule water-channel protein, which is involved in the regulation of the flow of water into and out of kidney cells.

In addition to its role in the regulation of water transport, ACSS1 has also been shown to play a role in the regulation of cell survival and proliferation. For example, studies have shown that ACSS1 can promote the survival and proliferation of brain cells, and that its absence can lead to the death and regression of these cells.

Given the importance of ACSS1 in the regulation of water transport in various body systems, it is a potential drug target. Studies have shown that inhibiting the activity of ACSS1 has been effective in treating a variety of conditions, including heart failure, neurodegenerative diseases, and kidney disease. Additionally, ACSS1 has been shown to be involved in several diseases, including Alzheimer's disease and cancer.

In conclusion, ACSS1 is a protein that plays a crucial role in the regulation of water transport in various body systems. Its ability to form a homo-dimeric complex with other APC proteins makes it a potential drug target, and its role in the regulation of cell survival and proliferation makes it a valuable tool for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of ACSS1 in the regulation of water transport and its potential as a drug target.

Protein Name: Acyl-CoA Synthetase Short Chain Family Member 1

Functions: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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