AOC3: A Potential Drug Target and Biomarker for Semicarbazide-Sensitive Amine Oxidase (SSAO)/(VAP-1)

Target Name: AOC3

NCBI ID: G8639

AOC3

AOC3: A Potential Drug Target and Biomarker for Semicarbazide-Sensitive Amine Oxidase (SSAO)/(VAP-1)

Introduction

Semicarbazide-sensitive amine oxidase (SSAO)/(VAP-1) is an enzyme involved in the metabolism of various amines, including neurotransmitters such as dopamine, serotonin, and endogenous opioids. The function of SSAO/VAP-1 is crucial in maintaining the Homeostasis of these neurotransmitters and is also involved in various physiological processes, including mood regulation, motivation, and pain perception.

Despite its importance, SSAO/VAP-1 is highly expressed in many tissues and has been implicated in various diseases, including neurodegenerative disorders, psychiatric disorders, and cancer. The only way to treat neurotransmitter-related disorders is to increase the activity of SSAO /VAP-1 or decrease its expression.

AOC3: A Unique Enzyme and Potential Drug Target

The encoded gene for SSAO/VAP-1, which encodes a 34-kDa protein, is located on chromosome 12q14.1 and has been named AOC3. AOC3 is a single transmembrane protein that plays a crucial role in the metabolism of neurotransmitters, including dopamine , serotonin, and endogenous opioids.

The AOC3 gene has been extensively studied and has been shown to encode a protein with a unique structure, including a catalytic domain, a transmembrane region, and a C-terminal region involved in post-translational modification (PtM). The AOC3 protein has a pI of 9.9 and a calculatedMr of 31,117.

AOC3 functions as a semicarbazide-sensitive amine oxidase, catalyzing the oxidation of amines to generate imidazoline derivatives. This reaction is critical in the metabolism of neurotransmitters, including dopamine and serotonin, which are involved in various physiological processes, including mood regulation, motivation, and pain perception.

AOC3 has also been shown to play a crucial role in the detoxification of endogenous opioids, such as codeine and morphine, and has been shown to reduce their toxicity. This function of AOC3 may have implications for the treatment of opioid dependence and abuse.

SSAO/VAP-1 and AOC3 are highly expressed in many tissues, including brain, heart, and peripheral tissues. The expression of AOC3 is regulated by various factors, including neurotransmitters, hormones, and diseases. For example, the levels of AOC3 have been shown to increase in the brains of individuals treated with dopamine agonists and to decrease in the brains of individuals treated with opioids.

Drugs that target AOC3 may have implications for the treatment of various psychiatric and neurological disorders, including neurodegenerative disorders, psychiatric disorders, and cancer. For example, drugs that increase the activity of AOC3, such as benzodiazepines, have been shown to be effective in treating anxiety disorders and depression.

Conclusion

SSAO/VAP-1 is an enzyme involved in the metabolism of various neurotransmitters and has been implicated in various diseases. The only way to treat neurotransmitter-related disorders is to increase the activity of SSAO/VAP-1 or decrease its expression. AOC3 is a unique enzyme that functions as a semicarbazide-sensitive amine oxidase and has been shown to play a crucial role in the metabolism of neurotransmitters.

AOC3 may also be a potential drug target for treating various psychiatric and neurological disorders. Drugs that target AOC3, such as benzodiazepines, may have implications for the treatment of anxiety disorders and depression. Further research is needed to fully understand the role of AOC3

Protein Name: Amine Oxidase Copper Containing 3

Functions: Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis

The "AOC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AOC3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets