Discovering APOBEC4 (ABEC4_HUMAN) as a Potential Drug Target and Biomarker

Target Name: APOBEC4

NCBI ID: G403314

APOBEC4

Other Name(s): ABEC4_HUMAN | putative C->U-editing enzyme APOBEC-4 | Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 | Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4 | apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4 | apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 | C1orf169 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) | Putative C->U-editing enzyme APOBEC-4

Discovering APOBEC4 (ABEC4_HUMAN) as a Potential Drug Target and Biomarker

Apoptosis, the process of natural cell death, is a crucial mechanism for tissue growth and development, as well as immune and inflammatory responses. dysregulated apoptosis has been implicated in numerous diseases, including cancer, neurodegenerative disorders, and systemic inflammatory diseases. The discovery of new biomarkers and potential drug targets can provide new insights into these conditions and lead to the development of more effective therapies. In this article, we will explore APOBEC4 (ABEC4_HUMAN) as a drug target and biomarker.

APOBEC4 (ABEC4_HUMAN) and its function

APOBEC4 is a member of the APOBEC family, which encodes small proteins involved in DNA protection and immune surveillance. The APOBEC4 gene encodes a protein that is expressed in many different tissues and cells, including epithelial, hematopoietic, and nervous system cells.

APOBEC4 functions as an immune evader, helping to protect the host against potential invading pathogens. By neutralizing foreign DNA, APOBEC4 enables the host to maintain a healthy immune response while minimizing the risk of immune-related diseases. In addition, APOBEC4 can also interact with the host's DNA to facilitate the formation of DNA-bound immune complexes, which can be targeted by the immune system for elimination.

Dysregulation of APOBEC4 has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. For example, studies have shown that high levels of APOBEC4 are associated with an increased risk of cancer, particularly lung and breast cancers. Additionally, research has linked APOBEC4 dysfunction to neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.

As a drug target, APOBEC4 can potentially be targeted by small molecules or antibodies to enhance the immune response and reduce the risk of disease. For instance, inhibition of APOBEC4 has been shown to enhance the efficacy of cancer vaccines in animal models. Additionally, antibodies against APOBEC4 have been shown to cross-react with various APOBEC4-expressing cell types, suggesting a potential for targeted therapies.

APOBEC4 (ABEC4_HUMAN) as a biomarker

The expression of APOBEC4 (ABEC4_HUMAN) is regulated by various factors, including DNA damage, cellular stress, and immune pressure. Therefore, its expression levels can be used as a biomarker to diagnose and monitor diseases associated with alterations in these factors.

In cancer, APOBEC4 (ABEC4_HUMAN) has been shown to be involved in the regulation of cell cycle progression, apoptosis, and angiogenesis. For example, studies have shown that high levels of APOBEC4 are associated with poor prognosis in breast and colorectal cancers. Additionally, inhibition of APOBEC4 has been shown to enhance the efficacy of anti-cancer agents in animal models.

In neurodegenerative diseases, APOBEC4 (ABEC4_HUMAN) has been implicated in the pathogenesis of various neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. For example, studies have shown that APOBEC4 levels are elevated in the brains of individuals with Alzheimer's disease, and that inhibition of APOBEC4 has been shown to reduce the neurotoxicity of neurodegenerative agents.

In autoimmune diseases, APOBEC4 (ABEC4_HUMAN) has been implicated in the development and progression of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. For example, studies have shown that high levels of APOBEC4 are associated with the development of autoimmune diseases, and that inhibition of APOBEC4 has been shown to reduce the impact of these diseases.

Conclusion

In conclusion, APOBEC4 (ABEC4_HUMAN) is a protein that plays a crucial role in the immune response and has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. As a drug target and biomarker, APOBEC4 has the potential to enhance the immune response and reduce the risk of disease. Further research is needed to fully understand the role of APOBEC4 in these diseases and to develop effective therapies.

Protein Name: Apolipoprotein B MRNA Editing Enzyme Catalytic Polypeptide Like 4

Functions: Putative C to U editing enzyme whose physiological substrate is not yet known

The "APOBEC4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about APOBEC4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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