Apob: Regulating Cholesterol and Inflammation (G338)

Target Name: APOB

NCBI ID: G338

APOB

Apob: Regulating Cholesterol and Inflammation

Apob (LDLCQ4) is a protein that is expressed in various tissues throughout the body. It is a member of the LDL cholesterol receptor family and is involved in the regulation of cholesterol levels in the body. Cholesterol is a crucial component of the cell membrane and is also used to produce hormones and bile. However, high levels of cholesterol in the blood can contribute to the development of heart disease and stroke, so it is important to maintain healthy cholesterol levels.

Apob is a 120-kDa protein that is expressed in the liver, heart, and kidneys. It is composed of two heavy chains and two light chains that are held together by disulfide bonds. The heavy chains contain four transmembrane domains, while the light chains contain one transmembrane domain and one cytoplasmic tail.

LDLCQ4 functions as a receptor for low-density lipoprotein (LDL) cholesterol, which is a major cholesterol in the blood. LDL cholesterol is a risk factor for the development of heart disease and stroke, so it is important to lower its levels in the body. Apob plays a key role in this process by regulating the levels of LDL cholesterol in the blood.

One of the functions of Apob is to regulate the levels of LDL cholesterol in the liver. The liver is the primary site of cholesterol synthesis and Apob is involved in the regulation of the synthesis and export of cholesterol from the liver. Apob promotes the production of low-density lipoprotein (LDL) cholesterol in the liver and inhibits the production of high-density lipoprotein (HDL) cholesterol. This allows for a balance of LDL and HDL cholesterol in the blood, which is important for maintaining good cholesterol levels.

Another function of Apob is to regulate the levels of LDL cholesterol in the body. Apob helps to remove LDL cholesterol from the bloodstream by binding to its receptor on the surface of the liver and transporting it into the liver for processing and removal. This process is known as uptake and apoptosis, and is important for maintaining a balance of LDL and HDL cholesterol in the body.

In addition to its role in regulating cholesterol levels, Apob is also involved in the regulation of inflammation in the body. inflammation

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Protein Name: Apolipoprotein B

Functions: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor

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