BAIAP3: A Potential Drug Target for Angiogenesis and Neurodegenerative Disorders

Target Name: BAIAP3

NCBI ID: G8938

BAIAP3

BAIAP3: A Potential Drug Target for Angiogenesis and Neurodegenerative Disorders

Brain-Specific Angiogenesis Inhibitor I-Associated Protein 3 (BAIAP3) is a protein that is expressed in various tissues of the brain, including the blood vessels, neurons, and glial cells. It is a member of the angiogenesis inhibitor protein (AIP) family , which is known for its role in the regulation of angiogenesis, the formation of new blood vessels, and the regression of existing blood vessels.

BAIAP3 is a 194 amino acid protein that is expressed in the brain, heart, and kidneys. It is primarily localized to the endothelial cells of the blood vessels, where it plays a role in the regulation of angiogenesis. Studies have shown that BAIAP3 is involved in the regulation of blood vessel diameter, permeability, and angiogenesis, and is a potential drug target for various cardiovascular and neurological diseases.

One of the key functions of BAIAP3 is its ability to inhibit the angiogenesis that occurs in response to increased blood flow. Angiogenesis is the process by which new blood vessels form in response to increased blood flow. This process is essential for the delivery of oxygen and nutrients to the brain, and is also involved in the formation of new blood vessels that can repair damaged blood vessels. However, an imbalance in angiogenesis can lead to the formation of abnormal blood vessels, which can contribute to the development of various cardiovascular and neurological diseases, such as heart disease, stroke, and Alzheimer's disease.

BAIAP3 is thought to work by inhibiting the activity of several angiogenesis-related genes, including those that are involved in the formation of blood vessels and the regulation of blood pressure. It is also possible that BAIAP3 interacts with other angiogenesis-related proteins, such as the bone marrow-derived stem cells (BMSCs) and the periapical cells, to further inhibit angiogenesis.

BAIAP3 has also been shown to be involved in the regulation of neuronal growth and differentiation. It has been shown to play a role in the regulation of neuronal excitability and synaptic plasticity, and is also involved in the regulation of neurotransmitter release and synaptic plasticity. These functions are important for the proper functioning of the brain and are likely to be involved in the development and progression of various neurological disorders.

In addition to its role in the regulation of angiogenesis and neuronal growth and differentiation, BAIAP3 is also thought to be involved in the regulation of inflammation. It has been shown to play a role in the regulation of immune cell function and the production of pro- inflammatory cytokines. This involvement in inflammation may contribute to the development of various inflammatory disorders, such as autoimmune diseases and chronic obstructive pulmonary disease (COPD).

Despite its potential role in the regulation of various physiological processes, BAIAP3 is not yet a well-studied drug target. There are currently no known drugs that are specifically designed to target BAIAP3, and research is needed to determine its full potential as a drug target.

In conclusion, BAIAP3 is a protein that is expressed in various tissues of the brain and is involved in the regulation of angiogenesis, neuronal growth and differentiation, and inflammation. While it is not yet a well-studied drug target, its potential role in the regulation of various physiological processes makes it an attractive target for future research. Further studies are needed to determine its full potential as a drug target and its potential therapeutic applications.

Protein Name: BAI1 Associated Protein 3

Functions: Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity)

The "BAIAP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BAIAP3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets