MED30 Complex Regulates TGF-β and PI3K/Akt Signaling Pathways

Target Name: MED30

NCBI ID: G90390

MED30

MED30 Complex Regulates TGF-β and PI3K/Akt Signaling Pathways

The MED30 (TRAP/Mediator complex component TRAP25) protein is a key regulator of cell signaling pathways that play a crucial role in the development and maintenance of tissues and organs. The MED30 protein is a member of the TRAP (Tyrosine-protein kinase-associated protein) family, which is known for its role in intracellular signaling.

TRAP25, a 25kDa protein, is a key component of the MED30 complex, which is composed of the protein MED30 and several other non-protein molecules. The MED30 complex plays a central role in regulating the activity of various signaling pathways, including the TGF-β pathway.

The TGF-β pathway is a critical regulator of cell growth, differentiation, and survival, and is involved in the development and maintenance of tissues and organs. The TGF-β pathway is activated by the binding of the TGF-β receptor to its extracellular domain, which leads to the formation of the complex between the TGF-β receptor and the MED30 protein.

The MED30 complex plays a crucial role in the regulation of the TGF-β pathway. The complex is able to inhibit the activity of the TGF-β receptor, which leads to the inhibition of TGF-β signaling. This negative regulation of TGF-β signaling is important for the maintenance of tissue homeostasis and the development and maintenance of tissues and organs.

In addition to its role in regulating TGF-β signaling, the MED30 complex is also involved in the regulation of several other signaling pathways, including the PI3K/Akt signaling pathway. This pathway is involved in the regulation of cell survival and growth, and is important for the development and maintenance of tissues and organs.

The MED30 complex is also involved in the regulation of several cellular processes that are important for the development and maintenance of tissues and organs. For example, the complex is able to regulate the activity of several enzymes that are involved in the production of extracellular matrix (ECM) components, such as collagen and elastin. These ECM components play a crucial role in the structure and function of tissues and organs, and the regulation of their production by the MED30 complex is important for the development and maintenance of these tissues and organs.

The MED30 complex is also involved in the regulation of several signaling pathways that are involved in the regulation of cell adhesion and migration. For example, the complex is able to regulate the activity of several proteins that are involved in cell adhesion and migration, including cadherins and vimentin. These proteins play a crucial role in the regulation of cell structure and function, and the regulation of their activity by the MED30 complex is important for the development and maintenance of tissues and organs.

In conclusion, the MED30 (TRAP/Mediator complex component TRAP25) protein is a key regulator of cell signaling pathways that play a crucial role in the development and maintenance of tissues and organs. The MED30 complex is able to inhibit the activity of the TGF-β receptor and is involved in the regulation of several other signaling pathways, including TGF-β, PI3K/Akt, and cell adhesion and migration. The regulation of these signaling pathways by the MED30 complex is important for the maintenance of tissue homeostasis and the development and maintenance of tissues and organs. Therefore, the MED30 protein is a potential drug target and a biomarker for the development of new therapeutic approaches for the treatment of various diseases.

Protein Name: Mediator Complex Subunit 30

Functions: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

The "MED30 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MED30 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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