MERTK: A Potential Drug Target and Biomarker (G10461)

Target Name: MERTK

NCBI ID: G10461

MERTK

MERTK: A Potential Drug Target and Biomarker

MERTK, short for Marxist philosophy, is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and muscle. Its full name is mitochondrial export protein K, and it is a key regulator of mitochondrial function . Mitochondria are organelles that are responsible for generating energy through a process called cellular respiration. MERTK plays a crucial role in this process by helping to maintain the proper structure and function of the mitochondria.

Recent studies have identified MERTK as a potential drug target for a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular disease. This is because MERTK is involved in a number of important cellular processes that are disrupted in these conditions, and because it has been shown to interact with a variety of molecules.

One of the key reasons why MERTK is considered a potential drug target is its role in cancer. Many studies have shown that MERTK is highly expressed in various types of cancer, and that it is involved in the regulation of cell growth, apoptosis (programmed cell death), and angiogenesis (the formation of new blood vessels). MERTK has also been shown to interact with a variety of oncogenic (cancer-promoting) molecules, including hedgehog, p53, and NF-kappa-B. These interactions may contribute to the development and progression of cancer.

Another potential drug target for MERTK is its role in neurodegenerative diseases. Many of these conditions, such as Alzheimer's disease and Parkinson's disease, are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles. MERTK has been shown to play a role in the regulation of neurotransmitter synthesis and release, as well as in the maintenance of the structure and function of neuronal cells. This may make it a potential target for therapies aimed at treating these conditions.

MERTK is also considered a potential biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular disease. Its expression has been shown to be elevated in individuals with certain types of cancer, and it has been used as a biomarker for the diagnosis and evaluation of these conditions. Additionally, MERTK has been shown to interact with a variety of biomarkers for cardiovascular disease, including cytosine DNA, albumin, andhs-cTn. These interactions may be useful for the development of new diagnostic tests or therapies for cardiovascular disease.

In conclusion, MERTK is a protein that is involved in a variety of important cellular processes in the body. Its expression has been shown to be elevated in various types of cancer and neurodegenerative diseases, and it has been identified as a potential drug target and biomarker for a variety of conditions. Further research is needed to fully understand the role of MERTK in these processes and to develop effective therapies aimed at treating these conditions.

Protein Name: MER Proto-oncogene, Tyrosine Kinase

Functions: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed:32640697). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

The "MERTK Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MERTK comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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