METAP2: A Potential Drug Target and Biomarker (G10988)

Target Name: METAP2

NCBI ID: G10988

METAP2

METAP2: A Potential Drug Target and Biomarker

METAP2, also known as Initiation factor 2-associated 67 kDa glycoprotein, is a protein that is expressed in various tissues and cells throughout the body. It is a member of the heat shock protein (HSP) family, which are proteins that are folded and simplified to survive high levels of thermal stress. METAP2 has been identified as a potential drug target and biomarker due to its unique structure, function, and involvement in various cellular processes.

The HSP family of proteins is characterized by the presence of a unique N-terminal hypervariable region (HVR1), which is involved in protein-protein interactions and regulation of protein stability. METAP2 is no exception to this rule, as it contains a highly conserved HVR1 that is involved in protein-protein interactions and regulation of protein stability.

One of the unique features of METAP2 is its localization to the endoplasmic reticulum (ER) and cytoplasm. It is primarily expressed in the ER, where it is involved in the loading and stability of various proteins. In addition, METAP2 is also expressed in the cytoplasm, where it is involved in various cellular processes such as protein folding, localization, and degradation. This dual localization of METAP2 to the ER and cytoplasm makes it a unique protein that is involved in the regulation of protein stability and localization.

METAP2 is also involved in the regulation of protein stability, which is a critical process for the survival of cells in various environments. High levels of thermal stress can cause proteins to become unstable and undergo a process of degradation, which can lead to a wide range of cellular consequences. METAP2 plays a role in the regulation of this process by helping to maintain protein stability.

METAP2 is also involved in the regulation of protein-protein interactions, which are critical for the regulation of cellular processes such as cell signaling, migration, and invasion. METAP2 is part of a complex that is involved in regulating protein-protein interactions, which is critical for the regulation of various cellular processes.

In addition to its role in protein stability and regulation, METAP2 is also involved in the regulation of protein synthesis. METAP2 is a key regulator of the translation of the heat shock protein (HSP) gene, which encodes the protein METAP2. This regulation of protein synthesis is critical for the regulation of cellular processes such as cell growth, apoptosis, and stress responses.

METAP2 is also involved in the regulation of protein degradation, which is a critical process for the regulation of cellular processes such as cell signaling, migration, and invasion. METAP2 plays a role in the regulation of protein degradation by helping to control the levels of the protein HSP70 in the cytoplasm.

METAP2 is also involved in the regulation of cell signaling, which is critical for the regulation of cellular processes such as cell growth, apoptosis, and stress responses. METAP2 plays a role in the regulation of cell signaling by helping to control the levels of the protein HSP70 in the cytoplasm.

In conclusion, METAP2 is a unique protein that is involved in the regulation of protein stability, stability, protein-protein interactions, and protein synthesis. Its localization to the ER and cytoplasm makes it a unique protein that is involved in the regulation of protein stability. and localization. METAP2 is also involved in the regulation of protein-protein interactions, and plays a key role in the regulation of protein synthesis and degradation. Given its unique structure and function, METAP2 is a potential drug target and biomarker.

Protein Name: Methionyl Aminopeptidase 2

Functions: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo

The "METAP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about METAP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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