MEPCE: A Tool for Modifying RNA Methylation State (G56257)

Target Name: MEPCE

NCBI ID: G56257

MEPCE

MEPCE: A Tool for Modifying RNA Methylation State

MEPCE (7SK snRNA methylphosphate capping enzyme) is a protein that plays a crucial role in regulating gene expression in many organisms. It is a member of the RNA methylation family and is responsible for modifying the methylation state of RNA molecules. The 7SK gene is located on chromosome 7 and encodes for a protein that has been shown to play a role in various cellular processes.

One of the unique features of MEPCE is its specificity for the methylation of the 7SK RNA molecule. It is able to add a methyl group to specific positions on the 7SK RNA molecule, and this process is highly specific to the target RNA. This specificity makes it a potential drug target or biomarker, as researchers can use this property to target and manipulate the expression of specific genes.

MEPCE is also involved in the regulation of gene expression in various organisms, including humans. It has been shown to play a role in the regulation of gene expression in cancer, and it is also involved in the regulation of gene expression in the development and progression of neurodegenerative diseases. This makes it an attractive target for researchers looking for new treatments for these diseases.

In addition to its potential as a drug target or biomarker, MEPCE also has important implications for basic cellular biology. The regulation of gene expression is a fundamental aspect of gene function, and it is involved in the development and maintenance of cellular identity and integrity. MEPCE is a key regulator of this process, and its study has the potential to shed light on the mechanisms of gene regulation in various organisms.

Overall, MEPCE is a protein that has significant implications for our understanding of gene regulation and the development of new treatments for various diseases. Further research is needed to fully understand its role in cellular processes and its potential as a drug target or biomarker.

Protein Name: Methylphosphate Capping Enzyme

Functions: S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723)

The "MEPCE Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MEPCE comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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