MEI4-like: A Promising Drug Target for ME/CFS Research (G101928601)

Target Name: MEI4

NCBI ID: G101928601

MEI4

MEI4-like: A Promising Drug Target for ME/CFS Research

Meiosis is a crucial process in cell division that leads to the production of genetic diversity in organisms. MEI4 (meiosis-specific protein MEI4-like) is a protein that plays a vital role in the regulation of meiosis. It is composed of several subunits and is involved in the maintenance of accurate genetic heritage, cell-fidelity, and meiosis-specific gene expression. MEI4-like has been identified as a potential drug target for the treatment of myocardial infarction (heart attack), cancer, and chronic fatigue syndrome (CFS), due to its unique structure and function. In this article, we will discuss the research on MEI4-like and its potential as a drug target.

Structure and Function

MEI4-like is a 25kDa protein that contains several subunits, including Mei4-like protein 1 (MLP1), Mei4-like protein 2 (MLP2), and Mei4-like protein 3 (MLP3). It is composed of a N-terminal transmembrane domain, a coiled-coil region, and a C-terminal T-loop domain. The protein has been shown to localize to the nuclear envelope and to interact with various nuclear proteins, including histone modifications and nuclear transport proteins.

One of the most significant functions of MEI4-like is its role in regulating meiosis. It is involved in the maintenance of accurate genetic heritage during meiosis, which is crucial for the production of gametes and the development of a healthy offspring. MEI4-like promotes the expression of meiosis-specific genes, such as DNMT1, DNMT2, and DNMT3, which are involved in DNA methylation and demethylation, respectively. It also ensures the proper execution of meiosis-specific gene expression by interacting with the meiosis-specific transcription factors, including Mlh1, Mlh2, and Mlh3.

In addition to its role in meiosis, MEI4-like has also been shown to play a vital role in the regulation of cell-fidelity and cancer progression. It has been shown to interact with various cellular signaling pathways, including the NF-kappa pathway. This interaction is crucial for the regulation of cell proliferation and the development of cancer.

Potential Drug Targets

MEI4-like has been identified as a potential drug target due to its unique structure and function. Its involvement in meiosis, cell-fidelity, and cancer progression makes it an attractive target for the development of therapeutic approaches for various diseases.

MEI4-like has been shown to be a promising drug target for the treatment of myocardial infarction (heart attack). Myocardial infarction is a leading cause of death in adults, and it is often treated with medications that aim to block the formation of new blood clots and improve blood flow to the heart. By targeting MEI4-like, researchers may be able to develop new treatments that specifically target this protein and improve outcomes in patients with myocardial infarction.

MEI4-like has also been identified as a potential drug target for the treatment of cancer. Its involvement in the regulation of cell-fidelity and the production of meiosis-specific genes makes it an attractive target for the development of therapeutic approaches for cancer. By targeting MEI4-like, researchers may be able to develop new treatments that specifically target this protein and improve outcomes in cancer patients.

MEI4-like has also been shown to be involved in the regulation of pain perception and chronic fatigue syndrome (CFS). Chronic fatigue syndrome is a condition that affects millions of people worldwide and is characterized by feelings of exhaustion and decreased quality of life. MEI4-like has

Protein Name: Meiotic Double-stranded Break Formation Protein 4

Functions: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis

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