HIPK3: A Potential Drug Target and Biomarker (G10114)

Target Name: HIPK3

NCBI ID: G10114

HIPK3

HIPK3: A Potential Drug Target and Biomarker

Hipk3 is a gene that encodes a protein known as histone-associated protein K3. This protein plays a critical role in the regulation of gene expression and has been linked to a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, HIPK3 has emerged as a promising drug target and biomarker for a variety of diseases.

The protein encoded by the HIPK3 gene is a 21-kDa protein that is highly conserved across various species. It is composed of a unique domain that includes a nucleotide-binding oligomerization domain (NBO), a zinc finger, and a carboxy-terminal domain. The NBO domain is responsible for the protein's nuclear localization and is involved in the regulation of gene expression. The zinc finger domain is involved in protein-protein interactions and is thought to play a role in the regulation of cellular processes such as cell growth, differentiation, and apoptosis. The carboxy-terminal domain is involved in the regulation of protein stability and localization in the cytosol.

HIPK3 has been shown to play a role in a variety of cellular processes, including cell growth, differentiation, and apoptosis. For example, studies have shown that HIPK3 is involved in the regulation of cell cycle progression and the G1/S transition. HIPK3 has also been shown to play a role in the regulation of cell apoptosis, as it has been shown to be involved in the execution of programmed cell death.

In addition to its role in cellular processes, HIPK3 has also been shown to be involved in the regulation of gene expression. For example, studies have shown that HIPK3 is involved in the regulation of the expression of target genes, including genes involved in cell growth, differentiation, and apoptosis. This suggests that HIPK3 may be a useful drug target for diseases associated with the regulation of gene expression, such as cancer and neurodegenerative diseases.

HIPK3 has also been shown to be involved in the regulation of protein-protein interactions, which is thought to play a role in the regulation of cellular processes such as cell signaling and signaling pathways. This suggests that HIPK3 may be a useful biomarker for diseases associated with the regulation of protein-protein interactions, such as neurodegenerative diseases.

In conclusion, HIPK3 is a gene that has been shown to play a role in a variety of cellular processes, including cell growth, differentiation, and apoptosis. As a result, HIPK3 has emerged as a promising drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of HIPK3 in disease and to develop effective treatments.

Protein Name: Homeodomain Interacting Protein Kinase 3

Functions: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE)

The "HIPK3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HIPK3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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