HLTF: A Potential Drug Target and Biomarker for Various Diseases

Target Name: HLTF

NCBI ID: G6596

HLTF

HLTF: A Potential Drug Target and Biomarker for Various Diseases

HLTF (RING finger protein 80) is a protein that is expressed in various tissues of the body, including the brain, heart, and liver. It is a member of the RING finger gene family, which is known for the involvement of transcription factor-mediated gene regulation. HLTF has been shown to play a role in various cellular processes, including cell signaling, DNA replication, and metabolism.

Drug Targeting

HLTF has been identified as a potential drug target due to its involvement in several diseases. One of the main reasons for its potential as a drug target is its involvement in cancer. Cancer is a disease that can be caused by the uncontrolled growth and proliferation of cells. HLTF has been shown to contribute to the development and progression of several types of cancer, including neurobladder cancer, breast cancer, and colorectal cancer.

In neurobladder cancer, HLTF has been shown to promote the growth and survival of cancer cells. Studies have shown that inhibiting HLTF can lead to a reduction in the growth and survival of neurobladder cancer cells. This is because HLTF plays a role in the development and maintenance of neurobladder cancer stem cells, which are the cells that give rise to the majority of neurobladder cancer tumors.

Another potential drug target for HLTF is its role in the development and progression of heart disease. Heart disease is a condition that can be caused by a variety of factors, including the buildup of plaque in the arteries. HLTF has been shown to contribute to the development and progression of heart disease by participating in the regulation of cell signaling and metabolism.

Biomarker

HLTF has also been identified as a potential biomarker for several diseases. One of the main reasons for its potential as a biomarker is its involvement in the regulation of cellular processes that are relevant to disease. For example, HLTF has been shown to play a role in the regulation of cell signaling, which is relevant to a wide range of diseases.

Some of the diseases that may be associated with changes in HLTF levels include neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These diseases are characterized by the progressive loss of brain cells and the development of characteristic symptoms. HLTF has been shown to play a role in the regulation of neurodegenerative diseases by participating in the development and maintenance of neurodegenerative stem cells.

Other diseases that may be associated with changes in HLTF levels include cancer, heart disease, and obesity. These diseases are characterized by the buildup of plaque in the arteries, the progression of cancer, and the development of obesity. HLTF has been shown to play a role in the regulation of cancer, heart disease, and obesity by participating in the regulation of cellular processes that are relevant to these diseases.

Conclusion

HLTF is a protein that has been shown to play a role in various cellular processes in the body. Its potential as a drug target and biomarker makes it an attractive target for research into the treatment of a wide range of diseases. Further studies are needed to fully understand the role of HLTF in disease and to develop effective treatments.

Protein Name: Helicase Like Transcription Factor

Functions: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA

The "HLTF Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HLTF comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets