HMGA1P4: A Drug Target / Disease Biomarker (G100506080)

Target Name: HMGA1P4

NCBI ID: G100506080

HMGA1P4

Other Name(s): high mobility group AT-hook 1 pseudogene 4 | High mobility group AT-hook 1 pseudogene 4

HMGA1P4: A Drug Target / Disease Biomarker

HMGA1P4, also known as HMG-1803, is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell proliferation and has been identified as a potential drug target for various diseases. In this article, we will discuss the science behind HMGA1P4 and its potential as a drug target.

HMGA1P4 is a member of the HMG-180 family of proteins, which are known for their role in regulating gene expression and DNA replication. The HMG-180 family consists of four proteins: HMGA1P2, HMGA1P3, HMGA1P4, and HMGA1P5. These proteins share a conserved catalytic core and share similar functions, such as the regulation of DNA replication, cell growth, and apoptosis.

HMGA1P4 is a 21-kDa protein that is expressed in various tissues, including the brain, heart, liver, and pancreas. It is highly conserved, with a calculated pI of 12.9 and a predicted localization in the cytoplasm. HMGA1P4 is a non-functional protein, which means that it does not have the ability to perform any biological function on its own. Instead, it acts as a negative regulator of the growth and development of cells.

One of the key functions of HMGA1P4 is its role in cell proliferation. It is well established that HMGA1P4 plays a negative role in cell proliferation by regulating the access of cell metaphors to the cell nucleus. This is done by blocking the ability of metaphors to bind to the nuclear envelope, which is the outermost layer of the cell nucleus. This blockade allows the cell to maintain a stable cytoskeleton and prevent excessive cell growth.

Another function of HMGA1P4 is its role in apoptosis. Apoptosis is a natural cell death that occurs in response to various stimuli, such as UV radiation, chemical insults, or cellular stress. HMGA1P4 has been shown to play a role in the regulation of apoptosis by promoting the production of pro-apoptotic transcription factors. This is done by the ability of HMGA1P4 to bind to and activate the transcription factors, such as p53, which are known to play a role in the regulation of apoptosis.

HMGA1P4 has also been shown to play a role in the regulation of cell migration. Cell migration is the movement of cells from one location to another in the body, and it is a critical process for the development and maintenance of tissues and organs. HMGA1P4 has been shown to play a role in the regulation of cell migration by regulating the production of the protein, called vimentin. Vimentin is a cytoskeleton protein that is involved in the formation of the cytoskeleton and is essential for cell migration.

In conclusion, HMGA1P4 is a protein that has been identified as a potential drug target for various diseases. Its functions in cell proliferation, apoptosis, and cell migration make it an attractive target for small molecule inhibitors. Further research is needed to fully understand the role of HMGA1P4 as a drug target and to develop effective treatments for various diseases.

Protein Name: High Mobility Group AT-hook 1 Pseudogene 4

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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