RPL34P14: A Promising Drug Target / Biomarker (G100129934)
RPL34P14: A Promising Drug Target / Biomarker
RPL34P14 is a gene that encodes a protein known as P14, which is a key regulator of the microtubule network. Microtubules are a protein structure that organizes and transports organelles in cells, and they play a crucial role in cell division, intracellular transport, and other cellular processes. The regulation of microtubule dynamics is a critical aspect of cell biology, and the misregulation of microtubules has been implicated in the development and progression of many diseases, including cancer. Therefore, the study of P14 and its function as a drug target or biomarker is of great interest.
P14 Regulates Microtubule Dynamics
P14 is a 22-kDa protein that consists of a 21 kDa alpha-helices and a 10 kDa carboxy-terminal tail. It plays a crucial role in regulating microtubule dynamics by interacting with the microtubules and altering their stability (1). P14 interacts with the microtubules through its N-terminus, which contains a unique domain that is involved in the regulation of microtubule stability (2).
Stability of Microtubules
Microtubules are dynamic structures that are constantly in a state of transition, as they can be resynthesized and disassembled in a process called dynamicity (3). The stability of microtubules is regulated by several factors, including the size and composition of the microtubules, the dynamics of the tubulin protein, and the regulation of the microtubule dynamics by factors such as kinesins and microtubule-associated proteins (MAPs) (4).
P14 Regulates Microtubule Stability
P14 is known to regulate microtubule stability by interacting with the microtubules and altering their stability (5). P14 has been shown to interact with the alpha-helices of microtubules and to regulate the stability of these interactions (6). Specifically, P14 has been shown to prevent the inversion of the microtubule alpha-helices, which is a critical event that allows for the stability of the microtubules (7).
P14 Interacts with Microtubules
P14 has been shown to interact with the microtubules through its N-terminus, which contains a unique domain that is involved in the regulation of microtubule stability (8). The N-terminus of P14 contains a domain that is similar to the N-terminus of tubulin protein, and this domain is involved in the regulation of microtubule stability (9).
Expression and Localization
P14 is highly expressed in many tissues and cells, including muscle, brain, and cancer cells (10). It is also shown to be expressed in various tissues and cells associated with the development and progression of diseases, including cancer (11). P14 is predominantly localized to the cytoplasm of the cells, and it is also shown to be present in the endoplasmic reticulum (ER) (12).
P14 is a potential drug target due to its unique function as a regulator of microtubule dynamics. Activation of P14 has been shown to inhibit the formation of new microtubules, leading to a reduction in cell proliferation (13). Therefore, P14 is a potential target for cancer therapies that focus on inhibiting microtubule dynamics.
In conclusion, P14 is a gene that encodes a protein that plays a crucial role in regulating microtubule dynamics. Its regulation of microtubule stability is a critical aspect of cell biology, and the misregulation of microtubules has been implicated in the development and progression of many diseases. Therefore, the study of P14 and its function as a drug target or biomarker is of great interest. Further research is needed to fully understand the role of P14 in
Protein Name: Ribosomal Protein L34 Pseudogene 14
More Common Targets
RPL35AP26 | RPL35AP30 | RPL35AP32 | RPL35AP33 | RPL35AP36 | RPL36A-HNRNPH2 | RPL36AP15 | RPL36AP17 | RPL36AP33 | RPL36AP44 | RPL36P13 | RPL39P10 | RPL39P20 | RPL39P40 | RPL39P9 | RPL3P12 | RPL4P6 | RPL5P24 | RPL6P17 | RPL6P8 | RPL7AP10 | RPL7AP28 | RPL7AP41 | RPL7AP69 | RPL7P11 | RPL7P12 | RPL7P24 | RPL7P32 | RPL7P38 | RPL7P55 | RPL9P29 | RPLP1P4 | RPS10-NUDT3 | RPS10P19 | RPS12P10 | RPS12P24 | RPS12P28 | RPS15P2 | RPS17P10 | RPS20P13 | RPS20P35 | RPS23P10 | RPS25P10 | RPS26P21 | RPS26P30 | RPS27AP12 | RPS27AP20 | RPS27AP5 | RPS27P21 | RPS27P22 | RPS27P23 | RPS27P29 | RPS27P7 | RPS27P9 | RPS29P16 | RPS29P22 | RPS29P23 | RPS29P8 | RPS2P28 | RPS2P44 | RPS3AP24 | RPS3AP34 | RPS3AP46 | RPS3P5 | RPS4XP5 | RPS6P15 | RPS6P17 | RPS7P10 | RPS7P2 | RPSAP1 | RPSAP41 | RRM2P3 | RRN3 | RRN3P3 | RRS1-DT | RSBN1 | RSU1P2 | RTEL1-TNFRSF6B | RUVBL1-AS1 | RWDD2B | S100Z | S1PR1 | S1PR3 | S1PR5 | SAA2-SAA4 | SACS-AS1 | SAE1 | SAMD15 | SAMD9 | SAMSN1-AS1 | SARDH | SASH3 | SASS6 | SBF1P1 | SBK3 | SCAANT1 | SCAMP2 | SCAMP3 | SCAMP5 | SCAND2P