Target Name: TESK2
NCBI ID: G10420
Review Report on TESK2 Target / Biomarker Content of Review Report on TESK2 Target / Biomarker
TESK2
Other Name(s): Dual specificity testis-specific protein kinase 2 | OTTHUMP00000009093 | testis-specific kinase 2 | TESK2_HUMAN | Testis associated actin remodelling kinase 2, transcript variant 1 | TESK2 variant 1 | testis associated actin remodelling kinase 2 | Dual specificity testis-specific protein kinase 2 (isoform 1) | testicular protein kinase 2 | Testicular protein kinase 2

TESK2: A Potential Drug Target and Biomarker for Specificity and Dysplasia in Squamous Carcinoma

Introduction

Squamous carinoma is a type of skin cancer that arises from the squamous epithelial cells, which line the skin. It is a common and often aggressive disease, with a high mortality rate and a significant impact on quality of life. Despite advances in surgery and radiation therapy, the treatment outcomes for squamous carinoma remain poor, highlighting the need for new therapeutic approaches. The TESK2 gene, which encodes a protein known as specificity and dysplasia (SOD), has emerged as a promising drug target and biomarker for this disease.

The TESK2 gene and its function

The TESK2 gene was identified as a gene that was highly expressed in squamous carinoma tissues compared to normal skin samples. It encodes a protein that contains two distinct domains: a N-terminal domain with a catalytic site and a C-terminal domain with multiple conserved secondary structural unit. The N-terminal domain is known as the TESK2 kinase domain, which is responsible for the protein's catalytic activity. The C-terminal domain includes a unique structural feature, known as a specificity and dysplasia (SOD) domain, which is involved in the regulation of cell proliferation and survival.

The SOD domain is a small protein that contains a unique Rossmann-fold, a structural motif that is commonly found in proteins that play a role in protein-protein interactions. The SOD domain is responsible for the regulation of the TESK2 protein's activity and stability. It has been shown to play a role in the regulation of cell growth, cell survival, and cell proliferation.

The potential clinical applications of TESK2 as a drug target

TESK2 has the potential to be a drug target for squamous carinoma because of its involvement in the regulation of cell proliferation and survival. By inhibiting the activity of the TESK2 protein, researchers may be able to reduce the growth and spread of squamous carinoma tumors. Additionally , TESK2 has been shown to be overexpressed in squamous carinoma tissues, which may make it an attractive target for small molecule inhibitors.

The potential biomarker applications of TESK2

TESK2 has the potential to serve as a biomarker for squamous carinoma because of its expression patterns in different types of cancer. Specifically, TESK2 has been shown to be highly expressed in squamous carinoma tissues, which may indicate its potential as a biomarker for this disease. Additionally, the TESK2 protein has been shown to be involved in the regulation of cell proliferation, which may make it an attractive target for biomarkers that reflect changes in cell behavior.

Conclusion

TESK2 is a gene that encodes a protein with significant potential as a drug target and biomarker for squamous carinoma. Its unique N-terminal and C-terminal domains, including the SOD domain, make it an attractive target for small molecule inhibitors. Additionally, its expression patterns in different types of cancer, including squamous carinoma, suggest its potential as a biomarker for this disease. Further research is needed to confirm the clinical and biological significance of TESK2 as a drug target and biomarker for squamous carinoma.

Protein Name: Testis Associated Actin Remodelling Kinase 2

Functions: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis

The "TESK2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TESK2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

TESMIN | TESPA1 | TET1 | TET2 | TET2-AS1 | TET3 | Tetraspanin | TEX10 | TEX101 | TEX11 | TEX12 | TEX13A | TEX13B | TEX13C | TEX14 | TEX15 | TEX19 | TEX2 | TEX21P | TEX22 | TEX26 | TEX261 | TEX264 | TEX28 | TEX29 | TEX30 | TEX33 | TEX35 | TEX36 | TEX36-AS1 | TEX37 | TEX38 | TEX41 | TEX43 | TEX44 | TEX45 | TEX46 | TEX47 | TEX48 | TEX49 | TEX50 | TEX52 | TEX53 | TEX55 | TEX56P | TEX9 | TF | TFAM | TFAMP1 | TFAP2A | TFAP2A-AS1 | TFAP2A-AS2 | TFAP2B | TFAP2C | TFAP2D | TFAP2E | TFAP4 | TFB1M | TFB2M | TFCP2 | TFCP2L1 | TFDP1 | TFDP1P2 | TFDP2 | TFDP3 | TFE3 | TFEB | TFEC | TFF1 | TFF2 | TFF3 | TFG | TFIID Basal Transcription Factor Complex | TFIIIC2 complex | TFIP11 | TFIP11-DT | TFPI | TFPI2 | TFPT | TFR2 | TFRC | TG | TGDS | TGFA | TGFA-IT1 | TGFB1 | TGFB1I1 | TGFB2 | TGFB2-AS1 | TGFB3 | TGFBI | TGFBR1 | TGFBR2 | TGFBR3 | TGFBR3L | TGFBRAP1 | TGIF1 | TGIF2 | TGIF2-RAB5IF | TGIF2LX