GACAT3: Key Enzyme in the Gastrin Cycle (G104797537)

Target Name: GACAT3

NCBI ID: G104797537

GACAT3

Other Name(s): LINC01458 | gastric cancer associated transcript 3 | Gastric cancer associated transcript 3 | lncRNA-AC130710

GACAT3: Key Enzyme in the Gastrin Cycle

GACAT3 (Gastrin-Releasing Adenylate Cyclase Type 3) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a key enzyme in the gastrointestinal cycle, which is responsible for the production of gastrin, a hormone that stimulates the production of stomach acid.

Gastrin is a 24-peptide hormone that plays a crucial role in the regulation of food intake and the rate of muscle contractions in the digestive tract. It is produced by the stomach cells that line the fundus of the intestine, and once it reaches the distal part of the intestine, it is transformed into gastrin by the GACAT3 enzyme.

The GACAT3 enzyme is a member of the family of cyclic ADP-ribose synthases (CARBS), which are a group of enzymes that catalyze the synthesis of cyclic ADP-ribose (cAMP) from its respective precursors. In the case of GACAT3, the precursor for cAMP is ATP, which is a key energy source for the cell.

Gastrin release is regulated by various factors, including the levels of food in the intestine, the presence of satiety hormones, and the brain's hunger and fullness signals. GACAT3 is also influenced by the amount of calories consumed, as it is known to have a role in the regulation of body weight.

In addition to its role in gastrin production, GACAT3 is also involved in the regulation of other physiological processes in the body. For example, it has been shown to play a role in the development and progression of cancer, particularly of the colon. It has also been linked to the regulation of inflammation, as well as the modulation of pain perception.

GACAT3 is also a potential drug target for several diseases, including cancer, obesity, and gastrointestinal disorders. For example, studies have shown that inhibiting the activity of GACAT3 has anti-tumor and anti-obesity effects. In addition, GACAT3 has been shown to be involved in the development of certain gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease.

Overall, GACAT3 is a protein that plays a critical role in various physiological processes in the body. Its function as a gastrin receptor and its involvement in the regulation of food intake, body weight, and other processes make it an attractive target for further research and develop as a potential drug.

Protein Name: Gastric Cancer Associated Transcript 3

The "GACAT3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GACAT3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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