GALNT4: Key Enzyme in UDP-GalNAc System (G8693)

Target Name: GALNT4

NCBI ID: G8693

GALNT4

GALNT4: Key Enzyme in UDP-GalNAc System

GALNT4 (UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 4) is a gene that encodes a protein located in the endoplasmic reticulum (ER) and known for its role in the modification of the carbohydrates on the surface of various cell types. The protein is composed of 214 amino acid residues and has a calculated molecular mass of 24.1 kDa.

GALNT4 is a key enzyme in the UDP-GalNAc system, which is involved in the transfer of the N-acetyl group to Galactosaminyl residues on various carbohydrates in the cell. This modification is important for various cellular processes, including cell signaling, tissue repair, and stress resistance.

GALNT4 is expressed in most tissues and cells, including the brain, pancreas, and muscle. It is also highly expressed in the placenta, suggesting a potential role in fetal development and growth.

GALNT4 has been shown to play a role in a variety of diseases and conditions, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that high levels of GALNT4 are associated with poor prognosis in patients with pancreatic ductal adenocarcinoma, a type of cancer that arises from the ducts that carry bile from the liver to the pancreas.

In addition to its potential role in disease, GALNT4 has also been shown to be a potential drug target. Several studies have shown that inhibiting GALNT4 activity can protect against the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Furthermore, GALNT4 has also been shown to be a potential biomarker for several diseases, including pancreatic cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that measuring the levels of GALNT4 in pancreatic cancer samples can be used to predict the effectiveness of targeted therapies.

In conclusion, GALNT4 is a highly conserved protein that plays a critical role in the UDP-GalNAc system. Its potential as a drug target and biomarker makes it an attractive target for further research into its functions and potential applications in medicine. Further studies are needed to fully understand the role of GALNT4 in disease and to develop effective treatments based on its modulation.

Protein Name: Polypeptide N-acetylgalactosaminyltransferase 4

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•   general information;
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