GAPDH: NAD-Driven Enzyme in Glucose Metabolism (G2597)

Target Name: GAPDH

NCBI ID: G2597

GAPDH

GAPDH: NAD-Driven Enzyme in Glucose Metabolism

GAPDH (NAD-dependent glyceraldehyde phosphate dehydrogenase) is an enzyme that plays a crucial role in the metabolism of glucose in the body. It is a key player in the glycolysis pathway, which is the first step in the breakdown of glucose to produce energy. GAPDH is found in all cells and is involved in the production of two key metabolites: NAD and FAD.

NAD is a critical coenzyme found in all cells that plays a vital role in various cellular processes, including energy metabolism, protein synthesis, and DNA replication. It is a dinucleotide, which means it consists of two nucleotides joined together. NAD+ is a crucial coenzyme that is involved in many cellular processes, including the metabolism of glucose.

FAD is a critical coenzyme found in all cells that is involved in various cellular processes, including energy metabolism and antioxidant responses. It is a tri nucleotide, which means it consists of three nucleotides joined together. FAD+ is a crucial coenzyme that is involved in the metabolism of glucose and other nutrients.

GAPDH is an enzyme that is involved in the production of NAD and FAD from NAD+ and FAD+, respectively. It is a NAD-dependent enzyme, which means that it requires NAD+ as a coenzyme to function. GAPDH catalyzes the reaction:

NAD+ + FAD+ + 2 NADH + 2 FADH2 鈫? NAD + FAD + 2 NAD+ + 2 FADH2 + 2 ATP

This reaction is critical for the metabolism of glucose and other nutrients. It is also involved in the production of other key metabolic products, including pyruvate, which is a key intermediate in the citric acid cycle.

GAPDH is found in all cells and is involved in various cellular processes, including metabolism, cell growth, and stress responses. It is a key regulator of the cellular response to changes in the environment, including changes in glucose levels.

GAPDH is a drug target (or biomarker) because of its involvement in the metabolism of glucose and other nutrients. It is a potential target for new drugs that can be used to treat a variety of diseases, including diabetes, heart disease, and neurological disorders.

GAPDH is also a biomarker for certain diseases, such as aging and certain forms of cancer. It is expressed at different levels in different tissues and cells, and its levels can be used as a diagnostic tool for certain conditions.

GAPDH is a NAD-dependent enzyme that is involved in the metabolism of glucose and other nutrients. It is a key regulator of the cellular response to changes in the environment and is a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of GAPDH in the metabolism of glucose and other nutrients and to develop new treatments based on its properties.

Protein Name: Glyceraldehyde-3-phosphate Dehydrogenase

Functions: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:3170585, PubMed:11724794). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:3170585, PubMed:11724794). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity)

The "GAPDH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GAPDH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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